Publications by authors named "Balvers K"
Article Synopsis
- The study examines the link between autonomic nervous system activity and immune response in patients with stroke or traumatic brain injury (TBI), focusing on nosocomial infections and their outcomes.
- Conducted between 2013 and 2016, the study analyzed heart rate variability (HRV) and immune responses in 64 patients, finding that 36% developed infections during their ICU stay.
- Results showed that infected patients had a weaker immune response and different HRV patterns, indicating a parasympathetic predominance that contributes to infection risk after brain injuries.
Essentials The response of thromboelastometry (ROTEM) parameters to therapy is unknown. We prospectively recruited hemorrhaging trauma patients in six level-1 trauma centres in Europe. Blood products and pro-coagulants prevent further derangement of ROTEM results.
View Article and Find Full Text PDFObjective: Developing pragmatic data-driven algorithms for management of trauma induced coagulopathy (TIC) during trauma hemorrhage for viscoelastic hemostatic assays (VHAs).
Background: Admission data from conventional coagulation tests (CCT), rotational thrombelastometry (ROTEM) and thrombelastography (TEG) were collected prospectively at 6 European trauma centers during 2008 to 2013.
Methods: To identify significant VHA parameters capable of detecting TIC (defined as INR > 1.
Background: The combined effects of balanced transfusion ratios and use of procoagulant and antifibrinolytic therapies on trauma-induced exsanguination are not known. The aim of this study was to investigate the combined effect of transfusion ratios, tranexamic acid and products containing fibrinogen on the outcome of injured patients with bleeding.
Methods: A prospective multicentre observational study was performed in six level 1 trauma centres.
Article Synopsis
- The study looked at how low body temperature (hypothermia) affects survival rates in trauma patients admitted to the ICU.
- Out of 953 patients, 354 had hypothermia, and it was linked to a higher chance of dying both soon after admission and later.
- The researchers created a prediction model to help determine which patients were at greater risk of dying based on factors like hypothermia, age, and injury severity.
Background: AB plasma is used as the universal donor plasma product in patients requiring massive transfusion. However, currently it is a recommended policy to transfuse plasma derived from male donors only as transfusion of plasma from HLA antibody-positive female donors is associated with an increased risk for transfusion-related acute lung injury. As a result, due to high demands, supplies of blood banks may run out of AB plasma, calling for alternatives.
View Article and Find Full Text PDFBackground: Massive transfusion protocols (MTPs) are increasingly used in the transfusion practice and are developed to provide the standardized and early delivery of blood products and procoagulant agents and to supply the transfusion of blood products in a well-balanced ratio.
Aim: The aim of this study was to investigate the effect of a hospital-wide introduction of an MTP on blood product ratio and a waste of blood products.
Materials And Methods: Retrospective analysis was performed to compare the transfusion practice in massive bleeding patients before and after the introduction of an MTP and between the use of an MTP and transfusion off-protocol.
Background: Both trauma-induced coagulopathy (TIC) and transfusion strategies influence early outcome in hemorrhagic trauma patients. Their impact on late outcome is less well characterized. This study systematically reviews risk factors for TIC- and transfusion-associated multiple organ failure (MOF) in severely injured trauma patients.
View Article and Find Full Text PDFIntroduction: Severe trauma affects the immune system, which in its turn is associated with poor outcome. The mediators driving the immune responses in trauma are largely unknown. The aim of this study was to investigate the role of endogenous microparticles (MPs) in mediating the immune response following severe trauma.
View Article and Find Full Text PDFIntroduction: Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagulability has prognostic value on the occurrence of multiple organ failure (MOF) and mortality.
Methods: This was a prospective observational cohort study in trauma patients who met the highest trauma level team activation.