Publications by authors named "Baltasar Lopez-Navarro"
Monocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial tissue-infiltrating macrophage subsets is associated with either active disease or inflammation resolution. JAK inhibitors (JAKi) are the first targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) approved for treatment of RA with comparable efficacy to biologics.
View Article and Find Full Text PDFMacrophages constitute important immune cell targets of the antifolate methotrexate (MTX) in autoimmune diseases, including rheumatoid arthritis. Regulation of folate/MTX metabolism remains poorly understood upon pro-inflammatory (M1-type/GM-CSF-polarized) and anti-inflammatory (M2-type/M-CSF-polarized) macrophages. MTX activity strictly relies on the folylpolyglutamate synthetase (FPGS) dependent intracellular conversion and hence retention to MTX-polyglutamate (MTX-PG) forms.
View Article and Find Full Text PDFArticle Synopsis
- * MTX alters the profile of macrophages, shifting them from a tumor-promoting type ("large TAM") to an antitumoral type ("small TAM") with specific gene expressions.
- * The reprogramming effect of MTX is linked to a reduction in the M-CSF receptor CSF1R and involves the GSK3β pathway, suggesting that targeting this pathway could enhance antitumor strategies that focus on macrophages.