IVC thrombosis: successful treatment with low dose streptokinase.

Thrombosis of the inferior vena cava (IVC) is an infrequent cause of thrombosis when large series of patients with deep vein thrombosis are examined. It may provide a diagnostic challenge in that lower extremity edema may be absent. The management has varied in published series with different authors recommending anticoagulant therapy (heparin or fibrinolytic therapy), surgical venous thrombectomy, or IVC interruption.

The effects of cimetidine on theophylline pharmacokinetics at steady state.

The effects of cimetidine on the pharmacokinetics of theophylline were studied in seven healthy subjects at steady state after oral dosing. Aminophylline (200 mg) was administered every six hours for three days (A), then aminophylline (200 mg) and cimetidine (300 mg) were administered every six hours for seven days (A-C). Multiple serum theophylline determinations were made after the last dose on each regimen using an enzyme immunoassay.

Effects of the respiratory cycle on cardiac output measurements: reproducibility of data enhanced by timing the thermodilution injections in dogs.

Cardiac output (Q) was measured with the thermodilution technique at 4 points during the respiratory cycle in dogs. Boluses of an ice-cold solution were injected at mid- and end-inspiration while the animals were on intermittent positive-pressure ventilation (IPPV) or after induction of positive end-expiratory pressure (PEEP), with and without induction of experimental respiratory failure. Values were mot constant at end-inspiration.

Effects of sighs and different tidal volumes on compliance, functional residual capacity and arterial oxygen tension in normal and hypoxemic dogs.

In order to assess the usefulness of sighs in preventing deterioration of arterial PO2 (PaO2), functional residual capacity (FRC), and compliance in hypoxemic patients, the authors studied 20 anesthetized and paralyzed dogs. The dogs were ventilated with either normal (11.5 ml/kg) or large (23 ml/kg) tidal volumes and their lungs were either normal or made edematous with oleic acid injection.

Caval catheter haemodialysis.

We describe a five-year experience using vena caval access for haemodialysis utilizing the McIntosh double-lumen catheter. A description of the catheter, method of insertion and of its performance including complications in 88 patients is given. The McIntosh catheter is a rapid, simple, effective and safe means of obtaining access for short-term haemodialysis.