Effects of word length and frequency on word identification in second- and fifth-grade children as a function of language skills.

The purpose of the current study was to examine the combined effect of word length and lexical frequency in a lexical decision task in second- and fifth-grade children with varying language skills. The participants, 47 second graders and 55 fifth graders, performed a lexical decision task in which word length and lexical frequency were manipulated orthogonally so that 32 words were short and frequent (e.g.

Effects of lexical skills and orthographic neighborhood size in word memory.

Two experiments were designed to investigate the relationship between individual lexical skills in young adults and memory performance on words varying by their orthographic neighborhood size. In Experiment 1, a sample of 100 university students were administrated a set of spelling, reading, and vocabulary tests to assess their lexical skills. Then, they had to learn mixed lists of words from high and low neighborhood size and perform free recall and memory recognition tasks.

Is the approach avoidance compatibility effect moderated by word imageability?

The approach/avoidance (AA) compatibility effect refers to the fact that individuals respond faster by an approach movement to positive than to negative stimuli, whereas they respond faster by an avoidance movement to negative than to positive stimuli. Although this effect has been observed in many studies, the underlying mechanisms remain still unclear. On the basis of recent studies suggesting a key role of sensorimotor information in the emergence of the AA compatibility effect, the present study aimed to investigate the specific role of visual information, operationalised through word imageability, in the production of the AA compatibility effect.

Individual and environmental determinants associated with longer times to access pediatric rheumatology centers for patients with juvenile idiopathic arthritis, a JIR cohort study.

Background: Despite guidelines, poor access to appropriate care for juvenile idiopathic arthritis (JIA) patients remains a global issue. Prompt referral to a pediatric rheumatology (PR) center and effective care is known to be critical for changing the natural history of the disease and improving long-term prognosis. This project assesses socio-economic factors of delayed referral to a pediatric rheumatologist (PRst) for JIA patients in France and Switzerland within the Juvenile Inflammatory Rheumatism (JIR) Cohort.

Word imageability influences the emotionality effect in episodic memory.

This study examines how and to what extent imageability influences the effect of word emotionality in episodic memory. A total of 52 young adults successively performed a free recall task and a recognition task in which word emotionality and imageability were orthogonally manipulated across six conditions of French words: low-imageability positive words (e.g.

[Method and impact of allografts cryopreservation during the Covid-19 pandemic: guidelines from the SFGM-TC].

The COVID-19 pandemic disorganized the allogeneic stem cell transplantation activities all over the world, with the necessity to cryopreserve allografts to secure the procedure for both the recipient and the donor. Cryopreservation, usually anecdotal, has been used by all the French speaking centers; data collected from 24 centers were assessed in order to determine the impact of cryopreservation on the quality of allografts. Our analysis clearly demonstrates that increasing transit time (more than 48hours) is deleterious for CD34 recovery, legitimates the slight increase of the requested CD34 cell dose with respect to the average recovery rate as well as the importance of the quality control on the infused product.

[Immunomonitoring of patients treated with CAR-T cells for hematological malignancy: Guidelines from the CARTi group and the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

CAR-T cells represent a new anti-tumor immunotherapy which has shown its clinical efficacy in B-cell malignancies. The results of clinical trials carried out in this context have shown that certain immunological characteristics of patients before (at the time of apheresis) and after the administration of the treatment, or of the CAR-T cells themselves, are correlated with the response to the treatment or to its toxicity. However, to date, there are no recommendations on the immunological monitoring of patients treated in real life.

Age-related evaluations of imageability and subjective frequency for 1286 neutral and emotional French words: ratings by young, middle-aged, and older adults.

This study aimed at providing imageability and subjective frequency ratings collected from four adult age groups ranging from 18 to 85 years old (18-25; 26-39; 40-59; and 60 and over) for 1286 neutral and emotional French words available in the EMA database (Gobin et al., 2017). Overall, the older adults rated words as more (subjectively) frequent and more imageable than the younger adults.

Word imageability and orthographic neighbourhood effects on memory: a study in free recall and recognition.

This study investigated the effects of word imageability and orthographic neighbourhood size, as well as their combined effects, in free recall and recognition memory. A total of 45 young adults performed recall and recognition tasks on the same word materials. Word imageability and orthographic neighbourhood size were orthogonally manipulated across four word conditions: low-imageability words - high , [], low-imageability words - low , [], high-imageability words - high , [] and high-imageability - low , [].

[How to perform leukapheresis for procurement of the staring material used for commercial CAR T-cell manufacturing: A consensus from experts convened by the SFGM-TC].

Chimeric antigen receptor (CAR) T-cells are a new class of cancer treatments manufactured through autologous or allogeneic T cells genetic engineering to induce CAR expression directed against a membrane antigen present at the surface of malignant cells. In Europe, tisagenlecleucel (Kymriah™) has a marketing authorization for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia in children and young adults and for the relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The marketing authorization for axicabtagene ciloleucel (Yescarta™) is the treatment of relapsed/refractory DLBCL and mediastinal B-cell lymphoma.

Therapeutic alliance is associated to treatment adherence in children with juvenile idiopathic arthritis.

Objectives: Therapeutic alliance (TA) is the agreement between caregiver and patient during the care process. Therapeutic adherence is a major issue for the management of Juvenile Idiopathic Arthritis (JIA) requiring child's strong ability to follow treatments. The aim of this study was to evaluate the relationship between TA and adherence in patients with JIA.

[Prerequisite for hematopoietic cellular therapy programs to set up chimeric antigen receptor T-cell therapy (CAR T-cells): Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

CAR T-cells are autologous or allogeneic human lymphocytes that are genetically engineered to express a chimeric antigen receptor targeting an antigen expressed on tumor cells such as CD19. CAR T-cells represent a new class of medicinal products, and belong to the broad category of Advanced Therapy Medicinal Products (ATMPs), as defined by EC Regulation 2007-1394. Specifically, they are categorized as gene therapy medicinal products.

Pregnancy after intracytoplasmic sperm injection following extended sperm preparation and hormone therapy in an azoospermic man with maturation arrest and microlithiasis: a case report and literature review.

In the management of azoospermia, a combination of testicular sperm extraction and intracytoplasmic sperm injection (ICSI) is usually the most successful option for fatherhood. However, an outstanding question remains: How can at least a few spermatozoa be obtained from the ejaculate, thus avoiding the need for a surgical procedure? A 36-year-old man presented to Assisted Reproduction Unit with his 26-year-old wife. The ultrasound assessment revealed bilateral microlithiasis.

The serum inhibin B concentration and reference ranges in normozoospermia.

Objective: Although an inhibin B assay may be useful in the assessment of testicular function in a number of genital conditions, reliable reference ranges are still lacking. The present study sought to establish the reference range for serum inhibin B by applying the updated Gen II assay.

Design: This prospective study included 818 men referred for semen analysis: 377 were normozoospermic (reference group) and 441 presented at least one abnormal semen parameter (case group).

Light microscopy morphological characteristics of the sperm flagellum may be related to axonemal abnormalities.

Although electron microscopy provides a detailed analysis of ultrastructural abnormalities, this technique is not available in all laboratories. We sought to determine whether certain characteristics of the flagellum as assessed by light microscopy were related to axonemal abnormalities. Forty-one patients with an absence of outer dynein arms (type I), a lack of a central complex (type III) and an absence of peripheral doublets (type IV) were studied.

Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production.

Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. Multiple intracellular targets of LamD, which affect cancer cell growth and induce apoptosis, have been identified. These include nuclear topoisomerase I, relevant kinases (such as cyclin-dependent kinase 2) and the mitochondrial electron transport chain.

Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction.

Aims: Development of metabolic syndrome is associated with impaired cardiac performance, mitochondrial dysfunction and pro-inflammatory cytokine increase, such as the macrophage migration inhibitory factor MIF. Depending on conditions, MIF may exert both beneficial and deleterious effects on the myocardium. Therefore, we tested whether pharmacological inhibition of MIF prevented or worsened metabolic syndrome-induced myocardial dysfunction.

Experimental designs for small randomised clinical trials: an algorithm for choice.

Background: Small clinical trials are necessary when there are difficulties in recruiting enough patients for conventional frequentist statistical analyses to provide an appropriate answer. These trials are often necessary for the study of rare diseases as well as specific study populations e.g.

[ICSI treatment in severe asthenozoospermia].

In the management of asthenozoospermia, the spermogram-spermocytogram plays an important role during diagnosis. It is of major importance to distinguish between necrozoospermia and sperm vitality. An ultrastructural study of spermatozoa is processed in the case of primary infertility without female implication, severe, unexplained and irreversible asthenozoospermia, sperm vitality at least 50 % and normal concentration of spermatozoa.

Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome.

Aims: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy.

Methods And Results: Mice were fed with normal diet (ND) or high-fat diet (HFD) for twelve weeks.