Chemical Variability and In Vitro Anti-Inflammatory Activity of Leaf Essential Oil from Ivorian (De Wild. & T. Durand) Engl. & Diels.

The chemical variability and the in vitro anti-inflammatory activity of the leaf essential oil from Ivorian were investigated for the first time. Forty-seven oil samples were analyzed using a combination of CC, GC(RI), GC-MS and C-NMR, thus leading to the identification of 113 constituents (90.8-98.

Five new cassane diterpenes from the seeds and bark of Erythrophleum suaveolens.

Five new cassane-type diterpenoid heterosides, i. e. two cassane-type amides (1-2), two erythrophlamine-type amine esters (3-4) and a non‑nitrogenous erythrophlamine analogue (5) were isolated from the root barks (1-2) and the seeds (3-5) of Erythrophleum suaveolens.

Crystal structure, Hirshfeld surface analysis and DFT studies of 2-(2,3-di-hydro-1-perimidin-2-yl)phenol.

The asymmetric unit of the title compound, CHNO, contains two independent mol-ecules each consisting of perimidine and phenol units. The tricyclic perimidine units contain naphthalene ring systems and non-planar CN rings adopting envelope conformations with the C atoms of the NCN groups hinged by 44.11 (7) and 48.

Crystal structure, Hirshfeld surface analysis and inter-action energy and DFT studies of 2-(2,3-di-hydro-1-perimidin-2-yl)-6-meth-oxy-phenol.

The title compound, CHNO, consists of perimidine and meth-oxy-phenol units, where the tricyclic perimidine unit contains a naphthalene ring system and a non-planar CN ring adopting an envelope conformation with the NCN group hinged by 47.44 (7)° with respect to the best plane of the other five atoms. In the crystal, O-H⋯N and N-H⋯O (Phnl = phenol and Prmdn = perimidine) hydrogen bonds link the mol-ecules into infinite chains along the -axis direction.

3-[2-(3-Phenyl-2-oxo-1,2-di-hydro-quin-oxalin-1-yl)eth-yl]-1,3-oxazolidin-2-one.

The di-hydro-quinoxaline ring system of the title mol-ecule, C19H17N3O3, is approximately planar [maximum deviation = 0.050 (2) Å], the dihedral angle between the planes through the two fused rings being 4.75 (8)°.

1-Phenyl-3H-2,3-benzodiazepin-4(5H)-one.

The seven-membered ring in the title compound, C(15)H(12)N(2)O, adopts a boat-shaped conformation (with the methyl-ene C atom as the prow and the double-bond C=N pair of atoms as the stern). In the crystal, adjacent mol-ecules are linked by an N-H⋯O hydrogen bond to generate helical chains running along the a axis of the ortho-rhom-bic unit cell.

3-{2-[(3-Phenyl-quinoxalin-2-yl)-oxy]ethyl}-1,3-oxazolidin-2-one.

The asymmetric unit of the title compound, C(19)H(17)N(3)O(3), consists of two independent mol-ecules that are disposed about a pseudo-centre of inversion. The plane of the phenyl substituent is twisted by 38.1 (1)° [43.

1-[2-(2-Oxo-1,3-oxazolidin-3-yl)eth-yl]-4-phenyl-1H-1,5-benzodiazepin-2(3H)-one.

The seven-membered ring in the title compound, C(20)H(19)N(3)O(3), adopts a boat conformation with the two phenyl-ene C atoms representing the stern and the methyl-ene C atom the prow. The dihedral angle between the best plane through the seven-membered ring (r.m.

Ethyl 2-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-1-yl)acetate.

The seven-membered ring in the title compound, C(19)H(18)N(2)O(3), adopts a boat conformation with the two phenyl-ene C atoms representing the stern and the methyl-ene C atom the prow. The dihedral angle between the best plane through the seven-membered ring (r.m.

1-Allyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one.

The seven-membered ring in the title compound, C(18)H(16)N(2)O, adopts a boat conformation with the two phenyl-ene carbons representing the stern and the methyl-ene C atom the prow. The dihedral angle between the best plane through the seven-membered ring and the phenyl ring is 62.13 (3)°.

3-[2-(3-Methyl-quinoxalin-2-yl-oxy)eth-yl]-1,3-oxazolidin-2-one.

Two isomers were isolated during the reaction between 3-methyl-quinoxalin-2-one and bis-(2-chloro-ethyl)amine hydro-chloride. The crystal structure of one isomer has already been reported [Caleb, Bouhfid, Essassi & El Ammari (2009). Acta Cryst.

1-Benzyl-3-[(dimethyl-amino)methyl-ene]-4-phenyl-1H-1,5-benzodiazepine-2(3H)-thione.

The title compound, C(25)H(23)N(3)S, crystallizes with two independent mol-ecules in the asymmetric unit. The seven-membered fused-ring adopts a boat conformation, with the two bridgehead C atoms representing the stern and the C atom bearing the exocyclic double bond the prow.