Publications by authors named "Balireddy Akula"
Several families of protein kinases have been shown to play a critical role in the regulation of cell cycle progression, particularly progression through mitosis. These kinase families include the Aurora kinases, the Mps1 gene product and the Polo Like family of protein kinases (PLKs). The PLK family consists of five members and of these, the role of PLK1 in human cancer is well documented.
View Article and Find Full Text PDFDiscovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
M V Ramana Reddy Balireddy Akula Stephen C Cosenza Saikrishna Athuluridivakar Muralidhar R Mallireddigari
J Med Chem
February 2014
Article Synopsis
- The success of imatinib for chronic myelogenous leukemia has spurred interest in developing new kinase inhibitors with lower toxicity.
- Researchers analyzed over 150 new cyano pyridopyrimidine compounds to identify trends for creating effective multikinase inhibitors.
- The lead compound, 7x, showed promising results by inducing tumor cell death at low concentrations and effectively inhibiting key kinases involved in cancer progression.