Publications by authors named "Balint Czako"
Article Synopsis
- Autoimmune pancreatitis (AIP) is often mistaken for pancreatic cancer, making diagnosis difficult, especially in cases requiring surgical intervention like pancreatic resection.
- A meta-analysis reviewed 10 studies, finding that 1.6% (140 cases) of patients who underwent pancreatic resection for suspected cancer actually had AIP, with 94% being type 1 AIP.
- The study highlights that current diagnostic methods are inadequate, as serum CA 19-9 levels do not effectively differentiate between AIP and pancreatic ductal adenocarcinoma (PDAC), leading to the risk of unnecessary surgeries.
Article Synopsis
- The study investigates how kynurenic acid (KYNA) and its synthetic analogues SZR-72 and SZR-104 impact blood-brain barrier (BBB) permeability and mitochondrial function in a rodent model of sepsis.
- It was found that sepsis leads to increased organ failure scores and elevated brain injury markers, indicating CNS dysfunction, which was reduced by treatment with KYNA and its analogues.
- The results suggest that KYNA may protect against sepsis-related brain damage by decreasing the levels of inflammatory markers and improving mitochondrial function.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with an overall 5-year survival of approximately 8%. The success in reducing the mortality rate of PDAC is related to the discovery of new therapeutic agents, and to a significant extent to the development of early detection and prevention programmes. Patients with new-onset diabetes mellitus (DM) represent a high-risk group for PDAC as they have an eightfold higher risk of PDAC than the general population.
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