Successful treatment of extensive cerebral venous sinus thrombosis using a combined approach with Penumbra aspiration system and Solitaire FR retrieval device.

We present a young woman with rapidly progressive neurologic decline in the setting of malignant cerebral edema due to extensive superior sagittal sinus thrombosis and cortical venous thrombosis despite intravenous heparin administration. Complete revascularization of the occluded sinus was achieved using suction thrombectomy with the 5 max Penumbra catheter in combination with the Solitaire FR clot retrieval device. The successful endovascular treatment halted the progression of her cerebral edema, and the patient eventually had an excellent recovery after prolonged intensive medical therapy.

Successful treatment of extensive cerebral venous sinus thrombosis using a combined approach with Penumbra aspiration system and Solitaire FR retrieval device.

We present a young woman with rapidly progressive neurologic decline in the setting of malignant cerebral edema due to extensive superior sagittal sinus thrombosis and cortical venous thrombosis despite intravenous heparin administration. Complete revascularization of the occluded sinus was achieved using suction thrombectomy with the 5 max Penumbra catheter in combination with the Solitaire FR clot retrieval device. The successful endovascular treatment halted the progression of her cerebral edema, and the patient eventually had an excellent recovery after prolonged intensive medical therapy.

Study of impact of antitubercular therapy on quality of life.

Introduction: Many aspects of tuberculosis (TB) and its treatment can compromise patients' quality of life (QOL). Treatment of active TB requires prolonged therapy with multiple drugs that can lead to adverse reactions. There is considerable social stigma associated with TB, leaving the individual feeling shunned and isolated.

MRI guides diagnostic approach for ischaemic stroke.

Background And Aim: Identification of ischaemic stroke subtype currently relies on clinical evaluation supported by various diagnostic studies. The authors sought to determine whether specific diffusion-weighted MRI (DWI) patterns could reliably guide the subsequent work-up for patients presenting with acute ischaemic stroke symptoms.

Methods: 273 consecutive patients with acute ischaemic stroke symptoms were enrolled in this prospective, observational, single-centre NIH-sponsored study.

MDCT evaluation of aortic valvular disease.

Objective: This essay depicts recent advances of MDCT in the evaluation of aortic valvular disease.

Conclusion: Aortic valvular disease can be assessed with current MDCT technology. The improved imaging characteristics of MDCT have significantly decreased artifacts traditionally seen with prosthetic aortic valves and enabled excellent visualization of valve function.

Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures.

The optimization of scaffold mechanical properties for neurite extension is critical for neural tissue engineering. Agarose hydrogels can be used to stimulate and maintain three-dimensional neurite extension from primary sensory ganglia in vitro. The present study explores the structure-function relationship between dorsal root ganglion (DRG) neurite extension and agarose gel mechanical properties.