Publications by Baldev Kumar Gautam

Publications by authors named "Baldev Kumar Gautam"

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Antidepressant-like activity of 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid (7a), a 5-HT₃ receptor antagonist in behaviour based rodent models: evidence for the involvement of serotonergic system.

Baldev Kumar Gautam Ankur Jindal Arghya Kusum Dhar Radhakrishnan Mahesh

Pharmacol Biochem Behav

August 2013

The present study was designed to investigate the putative antidepressant-like activity of 7a, a 5-HT₃ receptor antagonist, (although indirect evidence of 5-HT3 antagonism) with an optimal log P (3.35) and pA₂ value (7.6) greater than ondansetron (pA₂--6.

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- Baldev Kumar Gautam's research primarily focuses on the pharmacological effects of compounds influenced by serotonergic systems, particularly in relation to antidepressant-like activities.
- In his 2013 study, Gautam analyzed the effects of a specific compound, 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid, on behavior in rodent models, suggesting its potential as a 5-HT₃ receptor antagonist.
- The findings indicate that this compound exhibits antidepressant-like properties, with measurements indicating an optimal log P and pA₂ value that suggest it could outperform known medications like ondansetron.

Publications by authors named "Baldev Kumar Gautam"

Antidepressant-like activity of 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid (7a), a 5-HT₃ receptor antagonist in behaviour based rodent models: evidence for the involvement of serotonergic system.

Synopsis of recent research by authors named "Baldev Kumar Gautam"