Publications by authors named "Balazs Kui"
Article Synopsis
- Acute pancreatitis (AP) is a serious inflammation of the pancreas, and identifying patients at high risk of severe complications early is essential to prevent organ failure and death.
- The study developed a machine learning prediction model called EASY, using data from over 4,700 patients to offer quick assessments of severity through algorithms like XGBoost, achieving an average accuracy of 89.1%.
- The model identifies key risk factors such as respiratory rate, body temperature, and glucose level, and includes a user-friendly web application for easy access to its predictions.
Background: In severe acute pancreatitis (AP) the CNS is affected manifesting in neurological symptoms. Earlier research from our laboratory showed blood-brain barrier (BBB) permeability elevation in a taurocholate-induced AP model. Here we aimed to further explore BBB changes in AP using a different, non-invasive in vivo model induced by L-ornithine.
View Article and Find Full Text PDFOpioids are widely used for the pain management of acute pancreatitis (AP), but their impact on disease progression is unclear. Therefore, our aim was to study the effects of clinically relevant opioids on the severity of experimental AP. Various doses of fentanyl, morphine, or buprenorphine were administered as pre- and/or post-treatments in rats.
View Article and Find Full Text PDFThe pathophysiology of acute pancreatitis (AP) is not well understood, and the disease does not have specific therapy. Tryptophan metabolite L-kynurenic acid (KYNA) and its synthetic analogue SZR-72 are antagonists of the N-methyl-D-aspartate receptor (NMDAR) and have immune modulatory roles in several inflammatory diseases. Our aims were to investigate the effects of KYNA and SZR-72 on experimental AP and to reveal their possible mode of action.
View Article and Find Full Text PDFBackground: Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP.
View Article and Find Full Text PDFIntroduction: The incidence of acute pancreatitis (AP) and the prevalence of metabolic syndrome (MetS) are growing worldwide. Several studies have confirmed that obesity (OB), hyperlipidemia (HL), or diabetes mellitus (DM) can increase severity, mortality, and complications in AP. However, there is no comprehensive information on the independent or joint effect of MetS components on the outcome of AP.
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- Researchers examined the effectiveness of C-reactive protein (CRP) and white blood cell count (WBC) in assessing acute pancreatitis (AP) through a review of existing studies and data analysis of 1435 patient episodes.
- The study found that CRP levels were not reliable indicators of mortality or severity in AP cases, with low accuracy in predictions regardless of when the levels were measured.
- However, using CRP levels within the first 24 hours after pain onset as a criterion for including patients in clinical trials significantly increased the rates of severe cases and mortality, thus potentially simplifying the patient selection process for trials.
Due to the inappropriate use of antibiotics (AB), more pathogens become multiresistant. One of the most severe sources of sepsis is cholangitis. To avoid fatal outcome, an effective AB policy plays a key role.
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- This study investigates the effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) in treating acute biliary pancreatitis (ABP) in Hungary, highlighting the challenges of determining when to use the procedure.
- Out of 356 ABP patients, 75% underwent ERCP, but the procedure had suboptimal indicators, with biliary cannulation success rates at only 84% and higher complications in cases of unsuccessful cannulation and clearance.
- The research concludes that timely and effective ERCP is essential for better patient outcomes, as delays in performing the procedure can lead to increased local complications.
Article Synopsis
- Aging affects the outcomes of acute pancreatitis (AP), with severe comorbidities being a significant predictor of mortality and severity during the hospital stay.
- A study involving 1203 Hungarian patients showed that older age groups and higher comorbidity scores were linked to longer hospital stays and higher risks of complications.
- Middle-aged patients were notably more likely to experience pancreatic necrosis, while older patients faced a higher risk of systemic complications, indicating that both age and health status play critical roles in AP outcomes.
Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i) investigate the qualitative and quantitative changes of mucus both in human CP and in an experimental pancreatitis model and (ii) to correlate the mucus phenotype with epithelial ion transport function. Utilizing human tissue samples and a murine model of cerulein induced CP we measured pancreatic ductal mucus content by morphometric analysis and the relative expression of different mucins in health and disease. Pancreatic fluid secretion in CP model was measured by magnetic resonance cholangiopancreatography (MRCP) and on cultured pancreatic ducts.
View Article and Find Full Text PDFIntroduction: Chronic pancreatitis is an inflammatory disease associated with structural and functional damage to the pancreas, causing pain, maldigestion and weight loss and thus worsening the quality of life.
Aims And Methods: Our aim was to find correlations from a multicentre database representing the epidemiological traits, diagnosis and treatment of the disease in Hungary. The Hungarian Pancreatic Study Group collected data prospectively from 2012 to 2014 on patients suffering from chronic pancreatitis.
Article Synopsis
- The study focused on understanding the clinical characteristics and management of acute pancreatitis (AP) in a large group of patients across multiple centers in Hungary.
- It involved collecting data on 86 clinical parameters from 600 adult patients diagnosed with AP over a two-year span, identifying that biliary and alcoholic causes were the most prevalent.
- Key findings revealed that certain factors, like hyperlipidaemia and the absence of abdominal pain, were linked to increased severity and mortality, highlighting the importance of following established guidelines to improve patient outcomes.
Objective: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas.
Methods: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period.
Background And Aims: Pancreatic cancer is a devastating disease with poor prognosis. There is very limited information available regarding the epidemiology and treatment strategies of pancreatic cancer in Central Europe. The purpose of the study was to prospectively collect and analyze data of pancreatic cancer in the Hungarian population.
View Article and Find Full Text PDFA novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury.
Am J Physiol Gastrointest Liver Physiol
February 2016
We have previously shown that chenodeoxycholic acid (CDCA) strongly inhibits pancreatic ductal HCO3 (-) secretion through the destruction of mitochondrial function, which may have significance in the pathomechanism of acute pancreatitis (AP). Ursodeoxycholic acid (UDCA) is known to protect the mitochondria against hydrophobic bile acids and has an ameliorating effect on cell death. Therefore, our aim was to investigate the effect of UDCA pretreatment on CDCA-induced pancreatic ductal injury.
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- Animal models, especially L-arginine-induced pancreatitis in mice, are crucial for studying acute pancreatitis (AP) but show varying disease severity across studies.
- In experiments, BALB/c mice exhibited a low pancreatic necrosis rate (around 15%), while FVB/n and C57BL/6 mice showed significantly higher rates (approximately 50%).
- Findings suggest that factors like mouse strain, L-arginine concentration, and dosage impact AP outcomes, with no significant gender differences observed in severity.
Background & Aims: Excessive consumption of ethanol is one of the most common causes of acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) also cause pancreatitis. However, little is known about the role of CFTR in the pathogenesis of alcohol-induced pancreatitis.
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- Large doses of the amino acid L-arginine have been linked to severe pancreatic inflammation in both rats and mice, indicating a potential risk factor for pancreatitis.
- Other amino acids, like L-ornithine and L-lysine, also cause pancreatic damage, specifically affecting the exocrine part without harming the endocrine functions in rats.
- Research using these amino acid-induced pancreatitis models is gaining traction, as they mimic many characteristics of human pancreatitis, potentially aiding in understanding its causes and exploring treatment options.