The effect of Na-selenite treatment on the oxidative stress-antioxidants balance of multiple organ failure.

Purpose: Our study tested the hypothesis that sodium (Na)-selenite expression treatment can reduce oxidative stress and increase plasma antioxidants, whereas modulating white blood cell antigen expression in severe sepsis. Selenite is a well known cofactor of glutathione peroxidases and other antioxidant enzymes; therefore, one may expect an antioxidant effect of treatment.

Materials: We randomized 40 severe septic patients into treatment and control groups.

Microparticles and acute renal dysfunction in septic patients.

Purpose: The role of microparticles (MPs) in the pathogenesis of sepsis is not completely elucidated. We aimed to assess changes in the number of MPs during severe sepsis to follow the effect of sepsis-related organ failures, particularly renal impairment, an independent mortality factor of sepsis.

Materials And Methods: Thirty-seven severe septic patients and 20 controls were enrolled.