[Transmission of resistance to 1st and 2d generation cephalosporins].

The authors investigated the incidence of transferable resistance in bacterial strains resistant to cephalosporins of the first and second generation in the course of two years in materials of the microbiological department of one of the larger district hygiene stations. They recorded the development of the first strains resistant also to cephamandol, although this antibiotic is not used at all in the above area, and in exceptional instances also resistance to cephotaxime. It was revealed that the transferable resistance to cephamandol is due to the presence of an enzyme which hydrolyzes this antibiotic.