Abnormal cytoskeletal remodeling but normal neuronal excitability in a mouse model of the recurrent developmental and epileptic encephalopathy-susceptibility KCNB1-p.R312H variant.

Integrin_K Channel_Complexes (IKCs), are implicated in neurodevelopment and cause developmental and epileptic encephalopathy (DEE) through mechanisms that were poorly understood. Here, we investigate the function of neocortical IKCs formed by voltage-gated potassium (Kv) channels Kcnb1 and α5β5 integrin dimers in wild-type (WT) and homozygous knock-in (KI) Kcnb1 mouse model of DEE. Kcnb1 mice suffer from severe cognitive deficit and compulsive behavior.

Electron-Phonon Coupling in Copper-Substituted Lead Phosphate Apatite.

Recent reports of room-temperature, ambient pressure superconductivity in copper-substituted lead phosphate apatite, commonly referred to as LK99, have prompted numerous theoretical and experimental studies into its properties. As the electron-phonon interaction is a common mechanism for superconductivity, the electron-phonon coupling strength is an important quantity to compute for LK99. In this work, we compare the electron-phonon coupling strength among the proposed compositions of LK99.

Screening the organic materials database for superconducting metal-organic frameworks.

The increasing financial and environmental cost of many inorganic materials has motivated study into organic and "green" alternatives. However, most organic compounds contain a large number of atoms in the primitive unit cell, posing a significant barrier to high-throughput screening for functional properties. In this work, we attempt to overcome this challenge and identify superconducting candidates among the metal-organic-frameworks in the organic materials database using a recently proposed proxy for the electron-phonon coupling.

Probing multi-mobility edges in quasiperiodic mosaic lattices.

The mobility edge (ME) is a crucial concept in understanding localization physics, marking the critical transition between extended and localized states in the energy spectrum. Anderson localization scaling theory predicts the absence of ME in lower dimensional systems. Hence, the search for exact MEs, particularly for single particles in lower dimensions, has recently garnered significant interest in both theoretical and experimental studies, resulting in notable progress.

Spatiotemporal determination of photoinduced strain in a Weyl semimetal.

The application of dynamic strain holds the potential to manipulate topological invariants in topological quantum materials. This study investigates dynamic structural deformation and strain modulation in the Weyl semimetal WTe, focusing on the microscopic regions with static strain defects. The interplay of static strain fields, at local line defects, with dynamic strain induced from photo-excited coherent acoustic phonons results in the formation of local standing waves at the defect sites.

Terahertz electric-field-driven dynamical multiferroicity in SrTiO.

The emergence of collective order in matter is among the most fundamental and intriguing phenomena in physics. In recent years, the dynamical control and creation of novel ordered states of matter not accessible in thermodynamic equilibrium is receiving much attention. The theoretical concept of dynamical multiferroicity has been introduced to describe the emergence of magnetization due to time-dependent electric polarization in non-ferromagnetic materials.

Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients.

The aim of the study was to investigate the relationship between established clinical systemic biomarkers of ageing and the development of age-associated diseases and senescent cell biomarkers at tissue and cellular levels. Thirty-eight patients (mean age 70 ± 4.9 years) who were assessed for traditional risk factors for cardiovascular diseases were included.

Geometric Induction in Chiral Superfluids.

We explore the properties of chiral superfluid thin films coating a curved surface. Because of the vector nature of the order parameter, a geometric gauge field emerges and leads to a number of observable effects such as anomalous vortex-geometric interaction and curvature-induced mass and spin supercurrents. We apply our theory to several well-known phases of chiral superfluid ^{3}He and derive experimentally observable signatures.

Indoor radon exposure and its correlation with the radiometric map of uranium in Sweden.

Indoor radon concentrations are controlled by both human factors and geological factors. It is important to separate the anthropogenic and geogenic contributions. We show that there is a positive correlation between the radiometric map of uranium in the ground and the measured radon in the household in Sweden.

Urine TERT promoter mutations-based tumor DNA detection in patients with bladder cancer: A pilot study.

Telomerase reverse transcriptase (TERT) promoter mutations are the most frequent genetic events in bladder cancer (BC). The aim of the present pilot study was to evaluate the diagnostic potential of urine TERT promoter mutations-based liquid biopsy in patients with an ongoing oncological process, as well as in post-resection patients at risk of BC recurrence. A total of 60 patients were enrolled, of whom 27 patients had histologically proven BC; 23 had no signs of BC (control group); and 10 patients underwent transurethral malignancy resection 3-6 months prior to urine donation ('second look' group).

Axial Magnetoelectric Effect in Dirac Semimetals.

We propose a mechanism to generate a static magnetization via the "axial magnetoelectric effect" (AMEE). Magnetization M∼E_{5}(ω)×E_{5}^{*}(ω) appears as a result of the transfer of the angular momentum of the axial electric field E_{5}(t) into the magnetic moment in Dirac and Weyl semimetals. We point out similarities and differences between the proposed AMEE and a conventional inverse Faraday effect.

Thermal magnetic fluctuations of a ferroelectric quantum critical point.

Entanglement of two different quantum orders is of an interest of the modern condensed matter physics. One of the examples is the dynamical multiferroicity, where fluctuations of electric dipoles lead to magnetization. We investigate this effect at finite temperature and demonstrate an elevated magnetic response of a ferroelectric near the ferroelectric quantum critical point (FE QCP).

Proximity-Induced Odd-Frequency Superconductivity in a Topological Insulator.

At an interface between a topological insulator (TI) and a conventional superconductor (SC), superconductivity has been predicted to change dramatically and exhibit novel correlations. In particular, the induced superconductivity by an s-wave SC in a TI can develop an order parameter with a p-wave component. Here we present experimental evidence for an unexpected proximity-induced novel superconducting state in a thin layer of the prototypical TI, Bi_{2}Se_{3} proximity coupled to Nb.

Interacting Dirac materials.

We investigate the extent to which the class of Dirac materials in two-dimensions provides general statements about the behavior of both fermionic and bosonic Dirac quasiparticles in the interacting regime. For both quasiparticle types, we find common features for the interaction induced renormalization of the conical Dirac spectrum. We perform the perturbative renormalization analysis and compute the self-energy for both quasiparticle types with different interactions and collate previous results from the literature whenever necessary.

Erratum: Dynamic Multiferroicity of a Ferroelectric Quantum Critical Point [Phys. Rev. Lett. 122, 057208 (2019)].

This corrects the article DOI: 10.1103/PhysRevLett.122.

Gap-like feature observed in the non-magnetic topological insulators.

Non-magnetic gap at the Dirac point of topological insulators remains an open question in the field. Here, we present angle-resolved photoemission spectroscopy experiments performed on Cr-doped BiSe and showed that the Dirac point is progressively buried by the bulk bands and a low spectral weight region in the vicinity of the Dirac point appears. These two mechanisms lead to spectral weight suppression region being mistakenly identified as an energy gap in earlier studies.

Ubiquity of Superconducting Domes in the Bardeen-Cooper-Schrieffer Theory with Finite-Range Potentials.

Based on recent progress in mathematical physics, we present a reliable method to analytically solve the linearized Bardeen-Cooper-Schrieffer (BCS) gap equation for a large class of finite-range interaction potentials leading to s-wave superconductivity. With this analysis, we demonstrate that the monotonic growth of the superconducting critical temperature T_{c} with the carrier density n predicted by standard BCS theory, is an artifact of the simplifying assumption that the interaction is quasilocal. In contrast, we show that any well-defined nonlocal potential leads to a "superconducting dome," i.

Dynamic Multiferroicity of a Ferroelectric Quantum Critical Point.

Quantum matter hosts a large variety of phases, some coexisting, some competing; when two or more orders occur together, they are often entangled and cannot be separated. Dynamical multiferroicity, where fluctuations of electric dipoles lead to magnetization, is an example where the two orders are impossible to disentangle. Here we demonstrate an elevated magnetic response of a ferroelectric near the ferroelectric quantum critical point (FE QCP), since magnetic fluctuations are entangled with ferroelectric fluctuations.

Multiferroic quantum criticality.

The zero-temperature limit of a continuous phase transition is marked by a quantum critical point, which can generate physical effects that extend to elevated temperatures. Magnetic quantum criticality is now well established, and has been explored in systems ranging from heavy fermion metals to quantum Ising materials. Ferroelectric quantum critical behaviour has also been recently demonstrated, motivating a flurry of research investigating its consequences.

Conformational fingerprint of blood and tissue ACEs: Personalized approach.

Background: The pattern of binding of monoclonal antibodies (mAbs) to 18 epitopes on human angiotensin I-converting enzyme (ACE)-"conformational fingerprint of ACE"-is a sensitive marker of subtle conformational changes of ACE due to mutations, different glycosylation in various cells, the presence of ACE inhibitors and specific effectors, etc.

Methodology/principal Findings: We described in detail the methodology of the conformational fingerprinting of human blood and tissue ACEs that allows detecting differences in surface topography of ACE from different tissues, as well detecting inter-individual differences. Besides, we compared the sensitivity of the detection of ACE inhibitors in the patient's plasma using conformational fingerprinting of ACE (with only 2 mAbs to ACE, 1G12 and 9B9) and already accepted kinetic assay and demonstrated that the mAbs-based assay is an order of magnitude more sensitive.

Theory of combustion in disordered media.

The conventional theory of combustion describes systems where all of the parameters are spatially homogeneous. On the other hand, combustion in disordered explosives has long been known to occur after local regions of the material, called hot spots, are ignited. In this article we show that a system of randomly distributed hot spots exhibits a dynamic phase transition, which, depending on parameters of the system, can be either first or second order.

Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.

The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene.

Invariance of Topological Indices Under Hilbert Space Truncation.

We show that the topological index of a wave function, computed in the space of twisted boundary phases, is preserved under Hilbert space truncation, provided the truncated state remains normalizable. If truncation affects the boundary condition of the resulting state, the invariant index may acquire a different physical interpretation. If the index is symmetry protected, the truncation should preserve the protecting symmetry.