Correlation of serum trace elements (Fe, Cu, and Zn) in the blood samples of Indian patients with leukoplakia, oral squamous cell carcinoma, and normal subjects.

Context: Trace elements (iron, copper, and zinc), leukoplakia, and oral squamous cell carcinoma.

Aims: To study and correlate serum trace element (iron, copper, and zinc) levels in leukoplakia, oral squamous cell carcinoma, and normal subjects.

Settings And Design: The present study comprised a total of 80 patients, which included 30 patients of leukoplakia, 30 patients of oral squamous cell carcinoma, and the normal control group comprising 20 healthy individuals who were not having any relevant medical, dental, and habit history.

The micronucleus assay in the oral exfoliated cells of tannery workers.

Context: Micronuclei, tannery workers, chromium, papanicolaou (PAP) stain.

Aims: The presence of micronuclei are biomarkers broadly used; the detection of micronuclei offers a great opportunity to monitor individuals or populations exposed to mutagenic, genotoxic or teratogenic events, mainly the evaluation of micronucleogenic cells presence in epithelial tissues.

Settings And Design: Tannery workers with and without tobacco usage was considered for microneuceli assessment using PAP stain, 50 patients without usage of tobacco was taken and 50 patients with usage of tobacco was considered.

Identification of using different culture media and its association in leukoplakia and oral squamous cell carcinoma.

Context: , leukoplakia and oral squamous cell carcinoma.

Aims: The aim of the present study has assessed the association of with normal control group, leukoplakia and oral squamous cell carcinoma lesions of the oral cavity by using cornmeal broth +5% milk and milk serum liquid culture media.

Settings And Design: Thepresent study comprised of total 80 patients, which included, 30 patients of Leukoplakia, 30 patients of oral squamous cell carcinoma and normal control group comprised of 20 healthy individuals who were not having any relevant medical, dental and habit history.

Ultrastructural analysis of oral exfoliated epithelial cells of tobacco smokers and betel nut chewers: A scanning electron microscopy study.

Background: The study was undertaken to correlate epithelial surface pattern changes of oral exfoliated cells of tobacco smokers and betel nut chewers and also to compare them with patients of oral squamous cell carcinoma (OSCC) and healthy individuals.

Materials And Methods: In this cross-sectional study, a total of fifty persons were included in the study, out of which thirty formed the study group (15 each tobacco smokers and betel nut chewers) and twenty formed the control group (ten each of OSCC patients - positive control and ten normal buccal mucosa - negative control). Their oral exfoliated cells were scraped, fixed, and studied under scanning electron microscope (SEM).

Plexiform unicystic ameloblastoma: a case report and data analysis in the Indian population.

Unicystic ameloblastoma (UA) among the different types of ameloblastomas is least encountered. The reason for lack of perception is paucity of case reports published in the literature. The UA, first described by Robinson and Martinez in 1977, is relatively a rare type of ameloblastoma accounting for about 10-15 % of all ameloblastomas.

Origin of ameloblastoma from Basal cells of the oral epithelium- establishing the relation using neuroectodermal markers.

Background And Objectives: Basal cell layer of the oral epithelium has been rightfully regarded as a potential source of odontogenic tumours and cysts, but, without substantial evidence. Also, whether the basal cell layer retains within it, some properties of ectomesenchyme, which was imbibed during the early embryogenesis and hence its neuroectodermal relation, is not known. Here, an attempt is made to establish the hidden neuroectodermal potential of the oral epithelium, especially the basal layer, by observing the expression of known neuroectodermal markers, NSE (Neuron Specific Enolase), Synaptophysin and CD99.

Comparative study of various grading systems in oral squamous cell carcinoma and their value in predicting lymph node metastasis.

Background: Regional lymph node (LN) metastasis is the single most prognostic factor for oral squamous cell carcinoma (OSCC). An analysis of the prognostic factors is important for predicting prognosis and reducing the mortality in these patients.

Objectives: (1) To compare the value of various grading systems in predicting LN metastasis.

A study on mast cell number and lipid profile in oral submucous fibrosis.

Aims: Prevention of oral precancer is most desirable and should take precedence over its diagnosis and therapy. As both, mast cell counts in connective tissue and serum lipids are altered in Oral Submucous Fibrosis (OSF), so study of both the factors is vitally important in OSF.

Methods: A total of 50 persons were included in the study of which 40 were OSF patients and 10 controls.

Cyclin D1 an early biomarker in oral carcinogenesis.

Background: Dysregulation of cell cycle is a fundamental hallmark of cancer progression. Cyclin D1, part of complex molecular system regulating G1-S point of cell cycle is overexpressed in variety of tumors.

Aims: To look for its immunohistochemical expression in clinically normal mucosa from patients with and without tobacco habits, leukoplakia; and correlate its expression to individual atypical morphologic features, as seen in hematoxylin and eosin (H and E) sections of leukoplakia exhibiting dysplasia.

Methylene blue as an early diagnostic marker for oral precancer and cancer.

Oral cancer is one of the most common neoplasm's and is ranked eighth in the cancer incidence worldwide. Early detection is of critical importance because survival rates markedly improve. In vivo staining is a simple, inexpensive, and fairly sensitive method.

Fibrous dysplasia of the palate: report of a case and review of palatal swellings.

Fibrous dysplasia is a benign fibroosseous lesion characterised by the replacement of normal bone by excessive proliferation of cellular fibrous connective tissue which is slowly replaced by bone, osteoid, or cementum-like material. It causes bone pain, deformities, and pathological fractures. Fibrous dysplasia (FD) is a sporadic benign skeletal disorder that can affect one bone (monostotic form) or multiple bones (polyostotic form).

A huge adenomatoid odontogenic tumor of maxilla.

The adenomatoid odontogenic tumor (AOT) is a benign, nonneoplastic (hamartomatous) lesion with a slow progressing growth. It occurs in both intraosseous and peripheral forms. This paper reports the case of a female aged 16 years who presented with a swelling in anterior maxilla; canine was missing, and a supernumerary tooth was present in the mid line.

The expression of E-cadherin and cathepsin-D in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: A comparative analysis between immunohistochemistry and routine histopathology.

Background: E-cadherin is known to be an invasion suppressor gene and cathepsin-D, a protease, which is an invasion promoter and plays a central role in solid tumors including oral cancer.

Aims: To look for the expression pattern in normal buccal mucosa, dysplastic oral epithelium and oral squamous cell carcinoma (SCC) along with their correlation to individual atypical features, thereby providing an objective to the grading system in predicting the fate of affected epithelium.

Materials And Methods: To elucidate the expression patterns of these markers, we examined immunohistochemically on formalin fixed, paraffin embedded sections 22 dysplastic epithelia, eight SCC and ten normal buccal mucosa.

Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study.

Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC development and metastasis is evaluated in this study.