Publications by authors named "Balasubramanian Lakshman Kumar"
Runt-related transcription factor 3: single nucleotide polymorphism rs760805, gene expression, and methylation status in Helicobacter pylori -infected patients for determination of gastric cancer risk.
J Gastrointest Cancer
December 2013
Purpose: Repression of Runt-related transcription factor 3 (Runx3) gene, a tumor suppressor, has been known to be involved in Helicobacter pylori (H. pylori)-associated gastric carcinogenesis and cancer development. The present study was undertaken to study the Runx3 intronic T/A polymorphism (rs760805) in H.
View Article and Find Full Text PDFBackground And Aim: Longstanding ulcerative colitis (UC) predisposes to colorectal cancer (CRC). To understand the molecular pathogenesis of colitis-associated colorectal neoplasia (UC-CRN), we studied the frequency of microsatellite instability (MSI) and mutations in p53, BRAF and KRAS genes in the tissues of patients with long standing UC with or without neoplasia and compared them with colitis patients without risk of neoplasia, and those with sporadic colorectal neoplasia (S-CRN) in an area with lower prevalence for either disease.
Methods: Biopsies were obtained during magnifying chromo colonoscopy or routine colonoscopy in consecutive UC patients with high risk (UC-HR) and low risk (UC-LR) of neoplasia, and those with S-CRN.
Article Synopsis
- The study aimed to assess genetic alterations in residents of a high background radiation area in Tamil Nadu, India, comparing 108 exposed individuals with 108 control subjects.
- Findings showed higher frequencies of chromosomal alterations in the exposed group, predominantly of chromatid type, with lifestyle factors like smoking increasing these effects.
- Despite increased DNA damage indicated by comet assays, the study concluded that chronic low-level radiation does not significantly risk genetic damage based on conventional cytogenetic methods.