Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology.

Mitochondria, essential organelles responsible for cellular energy production, emerge as a key factor in the pathogenesis of neurodegenerative disorders. This review explores advancements in mitochondrial biology studies that highlight the pivotal connection between mitochondrial dysfunctions and neurological conditions such as Alzheimer's, Parkinson's, Huntington's, ischemic stroke, and vascular dementia. Mitochondrial DNA mutations, impaired dynamics, and disruptions in the ETC contribute to compromised energy production and heightened oxidative stress.

Novel Hybrid Quantum Architecture-Based Lung Cancer Detection Using Chest Radiograph and Computerized Tomography Images.

Lung cancer, the second most common type of cancer worldwide, presents significant health challenges. Detecting this disease early is essential for improving patient outcomes and simplifying treatment. In this study, we propose a hybrid framework that combines deep learning (DL) with quantum computing to enhance the accuracy of lung cancer detection using chest radiographs (CXR) and computerized tomography (CT) images.

Biohydrogen production coupled with wastewater treatment using selected microalgae.

Microalgae such as Chlorella pyrenoidosa, Scenedesmus obliquus and Chlorella sorokiniana were cultivated in domestic wastewater for biohydrogen production. The comparison between the microalgae was executed based on biomass productions, biochemical yields and nutrient removal efficiencies. S.

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies.

Purpose: This study aims to determine the analgesic activity of 1,4-dihydropyridine hybrid benzamide derivatives. These hybrid derivatives were synthesized, and their analgesic activity was studied. The synthesis method applied was a one-step reaction involving a green chemistry approach.

Solanum pubescens Wild Fruits Essential Oil - A Golden Casket for its Antimicrobial and Anti-inflammatory Mediated Wound Healing Efficacy in Vertebrate Model Mus musculus.

Background: Solanum pubescens Willd, growing wild in the hills of Rayadurg jurisdiction of Southwestern Andhra Pradesh, has gained significant attention among researchers for its diverse folkloric applications, existence of novel phytochemicals and leaf extracts which hold great medicinal promises. To date, the S. pubescens fruit's essential oil (SPO) has never been investigated.

Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.

Apolipoproteins (APO proteins) are the lipoprotein family proteins that play key roles in transporting lipoproteins all over the body. There are nearly more than twenty members reported in the APO protein family, among which the A, B, C, E, and L play major roles in contributing genetic risks to several disorders. Among these genetic risks, the single nucleotide polymorphisms (SNPs), involving the variation of single nucleotide base pairs, and their contributing polymorphisms play crucial roles in the apolipoprotein family and its concordant disease heterogeneity that have predominantly recurred through the years.

Statistical optimization of silver nanoparticle synthesis by green tea extract and its efficacy on colorimetric detection of mercury from industrial waste water.

For the optimization of silver nanoparticle production, a central composite design was used with three parameters: AgNO concentration, green tea extract concentration, and temperature at three different levels. The size of the synthesized silver nanoparticle, its UV absorbance, zeta potential, and polydispersity index were set as the response parameters. Silver nanoparticles obtained in the optimization process were characterized and its efficacy on colorimetric detection of mercury was evaluated.

Call for planning policy and biotechnology solutions for food waste management and valorization in Vietnam.

Food waste (FW) is more harmful than previously imagined. A large amount of Vietnam's FW ends up in landfills, only 20 % of which are sanitary. This causes significant environmental problems such as greenhouse gas emissions, high carbon footprint, leachate, and landfill-related conflicts.

Synthesis and characterization of proanthocyanidin-chitosan nanoparticles: An assessment on human colorectal carcinoma HT-29 cells.

Cancer nanotheranostic materials are helpful in monitoring drug delivery and efficacy against tumor cells. Current chemotherapeutic may have adverse side effects and this necessity to discover the new modern therapeutic nano-drugs. In the present study, we designed the new targeted and degradable polymer of bio-active chitosan nanoparticles with proanthocyanidin (PAC-CSNPs) and evaluated its apoptotic effects against human colorectal carcinoma cells (HT-29).

Two-step system consisting of novel vertical flow and free water surface constructed wetland for effective sewage treatment and reuse.

This study developed a unique system by combining the novel vertical flow (NVF) using expanded clay (ExC) and free flow surface constructed wetland (FWS) for dormitory sewage purification and reuse. The NVF tank consisted of filter layers of ExC, sandy soil, sand, and gravel. The FWS consisted of sandy soil substrate and was installed after the NVF.

Environmental friendly synthesis of TiO-ZnO nanocomposite catalyst and silver nanomaterilas for the enhanced production of biodiesel from Ulva lactuca seaweed and potential antimicrobial properties against the microbial pathogens.

TiO-ZnO heterogeneous catalytic system provides a good replacement of a homogeneous catalytic reaction due to its easier recovery. In this study, biodiesel was produced from Ulva lactuca seaweeds using TiO-ZnO nanocomposite catalysts with particle size of ~12 nm. The size controlled TiO-ZnO nanocomposite was characterized by powder XRD analysis and TEM.

A novel protease-immobilized carbon catalyst for the effective fragmentation of proteins in high-TDS wastewater generated in tanneries: Spectral and electrochemical studies.

The aim of this study was to degrade proteins in high-total dissolved solids (TDS)-containing wastewater produced during the soaking process in tanneries (tannery-TDS wastewater) using a halotolerant protease-assisted nanoporous carbon catalyst (STPNPAC). A halotolerant protease was obtained from the halophile, Lysinibacillus macroides, using animal fleshing as the substrate. The protease was immobilized using ethylene diamine (EDA)/glutaraldehyde functionalized nanoporous activated carbon (EGNPAC).

Intrinsic Mode Function Complexity Index Using Empirical Mode Decomposition discriminates Normal Sinus Rhythm and Atrial Fibrillation on a Single Lead ECG.

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia affecting approximately 3 million Americans, and is a prognostic marker for stroke, heart failure and even death. Current techniques to discriminate normal sinus rhythm (NSR) and AF from single lead ECG suffer several limitations in terms of sensitivity and specificity using short time ECG data which distorts ECG and many are not suitable for real-time implementation. The purpose of this research was to test the feasibility of discriminating single lead ECG's with normal sinus rhythm (NSR) and AF using intrinsic mode function (IMF) complexity index.