Effects of maze appearance on maze solving.

As mazes are typically complex, cluttered stimuli, solving them is likely limited by visual crowding. Thus, several aspects of the appearance of the maze - the thickness, spacing, and curvature of the paths, as well as the texture of both paths and walls - likely influence the performance. In the current study, we investigate the effects of perceptual aspects of maze design on maze-solving performance to understand the role of crowding and visual complexity.

The visual experience dataset: Over 200 recorded hours of integrated eye movement, odometry, and egocentric video.

We introduce the Visual Experience Dataset (VEDB), a compilation of more than 240 hours of egocentric video combined with gaze- and head-tracking data that offer an unprecedented view of the visual world as experienced by human observers. The dataset consists of 717 sessions, recorded by 56 observers ranging from 7 to 46 years of age. This article outlines the data collection, processing, and labeling protocols undertaken to ensure a representative sample and discusses the potential sources of error or bias within the dataset.

The role of texture summary statistics in material recognition from drawings and photographs.

Material depictions in artwork are useful tools for revealing image features that support material categorization. For example, artistic recipes for drawing specific materials make explicit the critical information leading to recognizable material properties (Di Cicco, Wjintjes, & Pont, 2020) and investigating the recognizability of material renderings as a function of their visual features supports conclusions about the vocabulary of material perception. Here, we examined how the recognition of materials from photographs and drawings was affected by the application of the Portilla-Simoncelli texture synthesis model.

Putting people in context: ERP responses to bodies in natural scenes.

The N190 is a body-sensitive ERP component that responds to images of human bodies in different poses. In natural settings, bodies vary in posture and appear within complex, cluttered environments, frequently with other people. In many studies, however, such variability is absent.

Not the norm: Face likeness is not the same as similarity to familiar face prototypes.

Face images depicting the same individual can differ substantially from one another. Ecological variation in pose, expression, lighting, and other sources of appearance variability complicates the recognition and matching of unfamiliar faces, but acquired familiarity leads to the ability to cope with these challenges. Among the many ways that face of the same individual can vary, some images are judged to be better of familiar individuals than others.

Assessing the impact of digital patient monitoring on health outcomes and healthcare resource usage in addition to the feasibility of its combination with at-home treatment, in participants receiving systemic anticancer treatment in clinical practice: protocol for an interventional, open-label, multicountry platform study (ORIGAMA).

Introduction: Digital patient monitoring (DPM) tools can enable more effective clinical care and improved patient outcomes in cancer. However, their broad adoption requires ease of use and demonstration of real-world clinical utility/impact. ORIGAMA (MO42720) is an interventional, open-label, multicountry platform study investigating the clinical utility of DPM tools and specific treatments.

Pharmacometric analyses of alectinib to facilitate approval of the optimal dose for the first-line treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer.

Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor approved for treatment of ALK-positive non-small cell lung cancer. Population pharmacokinetic (PK) models were developed for alectinib and its major active metabolite M4 using phase I/II PK data in crizotinib-failed patients (N = 138). The PK profiles were best described by two separate models with similar structure for both entities: open one-compartment models with sequential zero/first-order input and first-order elimination rate.

Robot faces elicit responses intermediate to human faces and objects at face-sensitive ERP components.

Face recognition is supported by selective neural mechanisms that are sensitive to various aspects of facial appearance. These include event-related potential (ERP) components like the P100 and the N170 which exhibit different patterns of selectivity for various aspects of facial appearance. Examining the boundary between faces and non-faces using these responses is one way to develop a more robust understanding of the representation of faces in extrastriate cortex and determine what critical properties an image must possess to be considered face-like.

Facial femininity and perceptions of eating disorders: A reverse-correlation study.

Eating disorders are prevalent in college students but college students are not accurate in identifying the presence of eating disorders (ED) especially when race is involved. Much has been researched about diagnostic ability in vignette form, but little outside of this. For example, it is not known how facial features, such as perceived femininity, may affect observers' beliefs about the likelihood of disordered eating depending on race.

Sensitivity to face animacy and inversion in childhood: Evidence from EEG data.

Adults exhibit relative behavioral difficulties in processing inanimate, artificial faces compared to real human faces, with implications for using artificial faces in research and designing artificial social agents. However, the developmental trajectory of inanimate face perception is unknown. To address this gap, we used electroencephalography to investigate inanimate faces processing in cross-sectional groups of 5-10-year-old children and adults.

The Fork-and-Knife Illusion.

We describe a transparency illusion that can be observed with an ordinary metal knife and fork. Placed in the correct configuration relative to the fork, the metal knife appears transparent, with some observers experiencing a bistable percept in which transparency alternates with reflective appearance. The effect is related to other illusory percepts that follow from careful placement of mirrored surfaces, but to our knowledge, it is unique in that the key feature of the illusion is how the mirrored surface (in this case, the knife) is perceived rather than how a mirror induces altered perception of other objects and surfaces.

To which world regions does the valence-dominance model of social perception apply?

Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions.

Reorganization in the representation of face-race categories from 6 to 9 months of age: Behavioral and computational evidence.

Prior research has reported developmental change in how infants represent categories of other-race faces (Developmental Science 19 (2016) 362-371). In particular, Caucasian 6-month-olds were shown to represent African versus Asian face categories, whereas Caucasian 9 month-olds represented different classes of other-race faces in one category, inclusive of African and Asian faces but exclusive of Caucasian faces. The current investigation sought to provide stronger evidence that is convergent with these findings by asking whether infants will generalize looking-time responsiveness from one to another other-race category.

Neural sensitivity to natural image statistics changes during middle childhood.

Natural images have properties that adults' behavioral and neural responses are sensitive to, but the development of this sensitivity is not clear. Behaviorally, children acquire adult-like sensitivity to natural image statistics during middle childhood (Ellemberg et al., 2012), but infants exhibit sensitivity to deviations of natural image structure (Balas & Woods, 2014).

Heart failure signs and symptoms, hospital referrals, and prescription patterns in patients receiving sacubitril/valsartan in primary care and cardiologist settings in Germany.

Aims: The aim of this paper was to analyse heart failure (HF) signs and symptoms, hospital referrals, and prescription patterns in patients receiving sacubitril/valsartan (sac/val) in primary care and cardiology settings in Germany.

Methods And Results: A retrospective cohort study of electronic medical records identified 1263 adults (aged ≥18 years) in the German IMS® Disease Analyzer database who were prescribed sac/val during 2016 and had at least 6 months of data following sac/val initiation. Clinical characteristics were collected during the 12 months before the first recorded sac/val prescription (index date) and 6 months post-index.

Distance learning in clinical medical education amid COVID-19 pandemic in Jordan: current situation, challenges, and perspectives.

Background: As COVID-19 has been declared as a pandemic disease by the WHO on March 11th, 2020, the global incidence of COVID-19 disease increased dramatically. In response to the COVID-19 situation, Jordan announced the emergency state on the 19th of March, followed by the curfew on 21 March. All educational institutions have been closed as well as educational activities including clinical medical education have been suspended on the 15th of March.

Electronic Cigarettes Prevalence and Awareness Among Jordanian Individuals.

The general awareness regarding E-smoking is varying from country to other depending on multivariable factors. We try to investigate the prevalence of E-Cigarette Awareness, Perceived Harmfulness, Prevalence, and Associations with Smoking-Cessation Outcomes among different age groups and different sex in Jordanian individuals. The study element shaped by data gathered from various questionnaire surveys.

Children are sensitive to mutual information in intermediate-complexity face and non-face features.

Understanding developmental changes in children's use of specific visual information for recognizing object categories is essential for understanding how experience shapes recognition. Research on the development of face recognition has focused on children's use of low-level information (e.g.

Children's use of local and global visual features for material perception.

Adults can rapidly recognize material properties in natural images, and children's performance in material categorization tasks suggests that this ability develops slowly during childhood. In the current study, we further examined the information children use to recognize materials during development by asking how the use of local versus global visual features for material perception changes in middle childhood. We recruited adults and 5- to 10-year-old children for three experiments that required participants to distinguish between shape-matched images of real and artificial food.

Pooled overall survival and safety data from the pivotal phase II studies (NP28673 and NP28761) of alectinib in ALK-positive non-small-cell lung cancer.

Objectives: A pooled analysis of two open-label phase II studies of alectinib (NP28673 [NCT01801111] and NP28761 [NCT01871805]) demonstrated clinical activity in patients with advanced, anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer (NSCLC) previously treated with crizotinib. Longer-term and final pooled analyses of overall survival (OS) and safety data from the two studies are presented here.

Patients And Methods: The pooled population totaled 225 patients (NP28673: n = 138, NP28761: n = 87) who received 600 mg oral alectinib twice daily until disease progression, death, or withdrawal.

Patient-reported outcomes from the randomized phase III ALEX study of alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer.

Objectives: Alectinib demonstrated superior efficacy and a safety profile that compared favorably with crizotinib in treatment-naïve ALK+ non-small-cell lung cancer (NSCLC) in the phase III ALEX study. We present patient-reported outcomes (PROs) from ALEX to assess disease burden, treatment-related symptom tolerability, and health-related quality of life (HRQoL) with alectinib versus crizotinib.

Materials And Methods: Patients were randomized to receive alectinib 600 mg or crizotinib 250 mg twice daily until disease progression, death, or withdrawal.

Mechanism of Action of Inhaled Insulin on Whole Body Glucose Metabolism in Subjects with Type 2 Diabetes Mellitus.

In the current study we investigate the mechanisms of action of short acting inhaled insulin Exubera®, on hepatic glucose production (HGP), plasma glucose and free fatty acid (FFA) concentrations. 11 T2D (Type 2 Diabetes) subjects (age = 53 ± 3 years) were studied at baseline (BAS) and after 16-weeks of Exubera® treatment. At BAS and after 16-weeks subjects received: measurement of HGP (3-H-glucose); oral glucose tolerance test (OGTT); and a 24-h plasma glucose (24-h PG) profile.