[Dual inhibition of VEGF-A and angiopoietin-2 in the treatment of neovascular age-related macular degeneration and diabetic macular edema].

The introduction of faricimab, a drug targeting both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2, has enabled the implementation of the highly effective dual inhibition strategy in real clinical practice for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), both previously treated with intravitreal injections and newly diagnosed. This article presents a series of 11 clinical cases involving patients with nAMD and DME who received loading doses of faricimab and continued ophthalmological observation. Among them, three patients with nAMD and two with DME were treatment-naïve, while the others were switched from alternative therapies to faricimab.

[The characteristics of the membrane-destabilizing mechanisms in chronic suppurative and suppurative-polypous sinusitis in children].

It is found that chronic purulent and pyopolypous sinusitis in children causes activation of lipid peroxidation and endogenic phospholipases in red cell membranes. There are shifts in structural and functional pattern of cytomembranes in inflammation focus (exudate from the sinuses). Membrane destabilization was maximal in pyopolypous sinus inflammation.

[The experimental action of helium-neon laser radiation on the tracheal and bronchial mucosa].

It has been shown that the energy of helium-neonium laser does not affect the tracheal and bronchial mucosa and does not induce tissue irreversible changes under the dose of 358 J/cm2. The sufficient parameters for good treatment are: -4.78 J/cm2, the density of power--7.

[Clinical aspects of metabolic nephropathies, interstitial nephritis and urolithiasis in calciphylaxis].

The problem of abacterial nephropathies associated with impaired calcium metabolism is discussed from the standpoint of membranous pathology. The data are presented on the similarity of the calciphylaxis pathogenesis described for the first time by H. Selye to calcium nephrolithiasis.

[Study of the enzymatic activity of the blood leukocytes in experimental nephrotoxic nephritis in rats].

The enzymatic activity of blood leukocytes was studied in rats with Masugi nephritis by means of the quantitative cytochemical method. Nephrotoxin injection during first hours and days did not produce specific changes in the enzymatic activity. Maximum changes were observed on the 8-th day when the elevation of the activity of dehydrogenase lymphocytes and neutrophils acid phosphatase was observed at the same time with most pronounced histological changes in the kidneys, the decrease of the complement titer and the presence of nephrotoxin and autoglobulin in the renal glomeruli.