Fear extinction is regulated by the activity of long noncoding RNAs at the synapse.

Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for their activity in this subcellular compartment in memory formation has yet to be demonstrated. Using lncRNA capture-seq, we identified a specific set of lncRNAs that accumulate in the synaptic compartment within the infralimbic prefrontal cortex of adult male C57/Bl6 mice.

Viable remediation techniques to cleansing wastewaters comprising endocrine-disrupting compounds.

Endocrine-disrupting chemicals (EDCs) have recently gained prominence as emerging pollutants due to their significant negative impacts on diverse living forms in ecosystems, including humans, by altering their endocrine systems. EDCs are a prominent category of emerging contaminants in various aquatic settings. Given the growing population and limited access to freshwater resources, their expulsion from aquatic systems is also a severe issue.

Carbon-based adsorbents as proficient tools for the removal of heavy metals from aqueous solution: A state of art-review emphasizing recent progress and prospects.

Carbon-centric adsorbents (CCA) are diverse forms, from simple biochar (BC) to graphene derivatives, carbon nanotubes (CNTs), and activated carbon (AC), which have been vastly explored for their removal of a plethora of pollutants, including heavy metals (HM). The prominent features of CCA are their operational attributes like extensive surface area, the occurrence of flexible surface functional groups, etc. This work offers a comprehensive examination of contemporary research on CCA for their superior metal removal aptitude and performances in simulated solutions and wastewater flows; via portraying the recent research advances as an outlook on the appliances of CACs for heavy metal adsorption for removal via distinct forms like AC, BC, Graphene oxide (GO), and CNTs.

Outlook on bismuth-based photocatalysts for environmental applications: A specific emphasis on Z-scheme mechanisms.

Semiconductor photocatalysis is thought to be a viable solution for addressing the growing problem of environmental pollution. Bismuth (Bi) metal oxides can function as a direct plasmonic photocatalyst or cocatalyst to accelerate the photogenerated charge separation and thus improve their photocatalytic activity. Hence, Bi-based photocatalysts have received a lot of attention due to their extensive environmental applications, including pollutant remediation and energy concepts.

Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling.

Homeostatic scaling in neurons has been attributed to the individual contribution of either translation or degradation; however, there remains limited insight toward understanding how the interplay between the two processes effectuates synaptic homeostasis. Here, we report that a codependence between protein synthesis and degradation mechanisms drives synaptic homeostasis, whereas abrogation of either prevents it. Coordination between the two processes is achieved through the formation of a tripartite complex between translation regulators, the 26S proteasome, and the miRNA-induced silencing complex (miRISC) components such as Argonaute, MOV10, and Trim32 on actively translating transcripts or polysomes.

Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway.

Development of functional synapses is crucial for the transmission and storage of information in the brain. Post establishment of the initial synaptic contact, synapses are stabilized through neuronal activity-induced signals. Emerging studies have implicated ubiquitination; a reversible posttranslational modification, as a key regulatory switch that modulates synapse development through proteasomal degradation.