Publications by authors named "Balakrishnan Senthil Kumar"
Article Synopsis
- A hospital-based study in Hyderabad, India examined the link between pesticide exposure and the levels of a cancer-associated biomarker (8-OHdG) in farmers and non-farmers with different types of cancers.
- The research revealed that farmers with leukemia had higher pesticide residue levels in their blood compared to those with lymphoma and breast cancer, while non-farmers and healthy individuals showed no such residues.
- The findings highlighted a significant correlation between one specific pesticide (profenofos) and elevated 8-OHdG levels, indicating a need for further research to explore these associations in larger groups.
Background: Cardiovascular diseases represent a significant global health burden, necessitating diverse approaches for effective management. Herbal interventions have gained attention as potential adjuncts or alternatives to conventional therapies due to their perceived safety and therapeutic potential. This structured abstract provides a comprehensive review of herbal interventions for the management of CVDs, summarising key findings, mechanisms of action, and clinical implications.
View Article and Find Full Text PDFBackground: Oxidative stress combined with nullity of xenobiotic metabolizing GSTT1/GSTM1/CYP2E1 genes may increase the susceptibility of agricultural workers to adverse health effects including cancer. The present study was conducted to determine; the prevalence of polymorphisms in GSTM1, GSTT1 and CYP2E1 genes, serum 8-hydroxy-2'-deoxygunosine levels, and the role of these markers in risk of cancer among agricultural workers occupationally exposed to pesticides.
Methods: A total of 360 participants, of which 180 belonging to farming group diagnosed with leukemia (n=60), lymphoma (n=60) and breast cancers (n=60), 90 in non-farming group diagnosed with similar cancers and the other 90 as healthy controls with neither history of occupational exposure nor diagnosed with any type of cancers were recruited.
Introduction: Although excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed to assess the impact of the use of PPE on the minimization of effects of exposure to pesticides among farm-workers.
Methods: A community-based follow-up study with questionnaire-based survey and field observations was undertaken among farm-workers ( = 180) of Rangareddy district, Telangana, India.