Publications by authors named "Balaji Gopalakrishnan"

Introduction Cellulitis is a prevalent bacterial skin infection, particularly affecting the lower limbs and often necessitating clinical intervention due to its considerable incidence rate. Factors like venous insufficiency, lymphedema, and recurring episodes increase the risk of relapse, complicating treatment strategies. Although antibiotics and limb elevation are standard care, severe cases may require surgical intervention.

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Background: Qurom quenching enzyme have an impact on treatment efficacy and prevent the recurrence of Helicobacter pylori biofilm-related infections, although it has not been thoroughly investigated in vitro and in silico. The current study aims to characterize the N-acyl homoserine lactonase, the quorum quenching AiiA protein of Bacillus licheniformis against H. pylori biofilm.

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Type 2 diabetes mellitus (T2DM), responsible for most diabetes cases recorded worldwide, increases the risk of chronic wounds and amputation. Patients with T2DM appear to be more susceptible to delayed wound healing due to their treatment adherence. This review explores the specifics of polypharmacy, side effects, possible drug interactions and the importance of medication adherence for therapeutic efficacy.

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Bacterial biofilm plays a vital role in influencing several diseases, infections, metabolic pathways and communication channels. Biofilm influence over colorectal cancer (CRC) has been a booming area of research interest. The virulence factors of bacterial pathogen have a high tendency to induce metabolic pathway to accelerate CRC.

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Background Rheumatoid arthritis (RA) is a widespread autoimmune disease affecting millions of people worldwide. The current markers include anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF), which are nonspecific and elevated in various conditions and do not have a prognostic value. They are also elevated in the later stages of the disease.

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Article Synopsis
  • Juvenile systemic sclerosis (JSSc) is a rare autoimmune disease mainly affecting kids and teens, linked to a mix of genetic, environmental, and immune factors.
  • The condition leads to excessive collagen production, causing symptoms like shortness of breath, chest pain, and kidney issues, though calcinosis cutis is uncommon in JSSc.
  • A case study discusses a 14-year-old girl with breathlessness and lesions who underwent surgery for calcinosis cutis, highlighting the importance of early diagnosis and treatment to prevent serious health risks.
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Background Acute ischemic stroke, a clinical disorder caused by nontraumatic cerebrovascular disease, has an acute onset, frequently causes neurological deficit, and may persist for >24 hours or can be fatal in <24 hours. This study aimed to assess the red cell width distribution (RDW) and the mean platelet volume (MPV) in predicting 30-day mortality in acute ischemic stroke patients. In general, patients with acute ischemic stroke have a rather high mortality rate in the first 30 days due to various complications, but post the 30-day mark, the prognosis is comparatively better.

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Background: Currently, most old age homes in India are completely occupied. Nowadays, nuclear families are more than joint families, and due to various factors such as urbanization, the elderly are deprived of essential care at home and are moved from their own homes to old-age homes. With the increasing geriatric population, this study explored the various social factors influencing the elderly to reside in old age homes.

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While various methods exist for synthesizing silver nanoparticles (AgNPs), green synthesis has emerged as a promising approach due to its affordability, sustainability, and suitability for biomedical purposes. However, green synthesis is time-consuming, necessitating the development of efficient and cost-effective techniques to minimize reaction time. Consequently, researchers have turned their attention to photo-driven processes.

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In most developing countries, the availability of drinking water is a major problem. This creates the need for treatment of wastewater, reusability of water, etc. The membrane technology has its place in the market for treating such water.

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Background: Obesity is an important public health problem and is on the rise among adolescents in developed and developing nations. This case-control study was done to assess the dietary risk factors associated with obesity among school children of the adolescent age group.

Materials And Methods: This study was done among age-matched 110 cases and 110 controls who were adolescent children between ages 10 and 17 years.

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Water scarcity and salinity are major challenges facing agriculture today, which can be addressed by engineering plants to grow in the boundless seawater. Understanding the mangrove plants at the molecular level will be necessary for developing such highly salt-tolerant agricultural crops. With this objective, we sequenced the genome of a salt-secreting and extraordinarily salt-tolerant mangrove species, Avicennia marina, that grows optimally in 75% seawater and tolerates >250% seawater.

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Introduction: Although various measures are taken to create awareness about the epidemiological features of leprosy and encourage health-seeking behavior, they have seldom been able to tackle the high incidence of new leprosy cases in India.

Objective: To determine Leprosy-related knowledge, attitude, and health seeking behavior among the urban population in Kancheepuram district of Tamil Nadu.

Materials And Methods: This community-based cross-sectional study was conducted among a sample size of 640 people above 18 years of age residing in the study area, selected by multistage random sampling.

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Introduction: Rabies is a neglected zoonotic tropical disease that usually affects the poorest communities. Rabies is 100% fatal and at the same time 100% preventable. A huge proportion of death due to rabies occurs in Asia and Africa, and India is reported to have the highest incidence of rabies.

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Article Synopsis
  • * Participants were divided into two groups, with one receiving platelet-rich plasma treatment and the other not, followed by assessments for pain and healing over two weeks.
  • * Results showed a significant reduction in pain and faster healing in patients who received the platelet-rich plasma, indicating it could be a beneficial intervention post-surgery.
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<b>Background:</b> Mucormycosis is a rare fungal infection affecting people with impaired immunity. The aim of this study is to shed light on the epidemiology, incidence, and outcome of patients with mucormycosis hospitalized at a tertiary care center in Pondicherry. <br><b>Methods:</b> We conducted a retrospective chart review between January 2008 and January 2018.

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One of the most important products of global addiction demand is an alcoholic beverage. In developing countries like India, alcohol consumption tends to be a major problem because of the various socio-cultural practices across the nation, different alcohol policies and practices across the various states, lack of awareness of alcohol-related problems among the community, false mass media propaganda about alcohol use, various alcohol drinking patterns among the alcohol consumers and the emergence of social drinking as a habit because of the widespread urbanisation across the country. Stringent alcohol policies are needed across the various states to reduce alcohol consumption, and alcohol consumers have to be educated about the various harmful effects of alcohol consumption and the effects it can have on their mind, body and soul.

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Article Synopsis
  • Helicobacter pylori can create biofilms and resist antibiotics, making treatment difficult and increasing the risk of certain cancers.
  • This study investigates N-acylhomoserine lactonase stabilized silver nanoparticles (AiiA-AgNPs) as a potential solution, which disrupt biofilm formation and other harmful processes in H. pylori.
  • AiiA-AgNPs are non-toxic to macrophages at therapeutic concentrations but can be harmful to cancer cells at higher doses, showing promise for cancer treatment.
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Medical devices used in a home setting for treating a variety of chronic diseases lack the ability to convey meaningful information to the patients directly about how they are engaging with their devices in real-time. This research is focused on the development of a monitoring system that addresses this need. For this initial design and testing, the research team applied the technology to a positive airway pressure (PAP) system used in the treatment of those suffering from obstructive sleep apnea (OSA).

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Introduction: Reproductive health of women is of special concern, especially during their reproductive years where the reproductive morbidity is very high, especially in countries like India.

Aims: This study was carried out to find the reproductive health status of rural married women and identify those suffering from reproductive morbidity to provide appropriate guidance and treatment.

Methodology: This community-based cross-sectional descriptive study was carried among rural married women above 18 years of age in the field practice areas of a medical college.

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Introduction: In India, though the prevalence of alcohol consumption is low, nearly half of the alcoholic consumers fall into the category of hazardous drinking. There have been rapid changes in the trends and pattern of alcohol use in India.

Aims: The study was carried to find out the pattern of alcohol consumption, associated morbidities, and its association with related factors in an urban area of Tamil Nadu.

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Introduction: In India, the ever increasing production, promotion, distribution, and the easy availability and accessibility of alcohol together with the changing values in the society have resulted in alcohol consumption becoming one of the major public health problems.

Aims: The study was undertaken to find out the prevalence of alcohol consumption and its epidemiological determinants in an urban area of Kancheepuram district, Tamil Nadu.

Methodology: This descriptive cross-sectional study was done among adult males above 18 years of age in Anakaputhur area of Kancheepuram district, Tamil Nadu.

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Introduction: Maternal morbidity and mortality is still a major public health challenge. Lack of proper birth plan and delay in identification of pregnancy complications is one of the major causes of maternal morbidities and deaths, especially in the rural areas.

Aim: The study was conducted with the aim to evaluate the health-seeking behaviour for obstetric care services among the antenatal and postnatal mothers in a rural area of Tamil Nadu.

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Introduction: In India, intestinal parasitic infection and anemia remain the most important cause of morbidity especially among the adolescent school children due to lack of awareness of personal hygiene practices, leading to intestinal parasite infections which could in turn lead to anemia.

Aim: This study was conducted with the aim to find out the prevalence of intestinal parasitic infection and anemia among adolescent female school children in an urban area of Tamil Nadu.

Materials And Method: This descriptive cross-sectional study was done among adolescent female school children in Anakaputhur area of Kancheepuram district.

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Introduction: Acute respiratory infection (ARI) is an infection of the respiratory tract. It may interfere with normal breathing of the individual and is communicable in nature. There are several modifiable risk factors that predispose younger age group of children to ARI.

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