Publications by authors named "Balaji D Sathe"
Article Synopsis
- * Researchers designed new drug candidates by hybridizing two pharmacophoric systems, leading to the creation of novel molecules (1K1-1K5) using a multi-step synthesis method.
- * The new compounds showed promising effectiveness in inhibiting MERTK, particularly IK5, which had low IC values against various cancer cell lines, and demonstrated good stability and clearance profiles for further testing.
Article Synopsis
- Signaling through the CSF1R receptor is crucial for attracting and differentiating tumor-associated macrophages (TAMs), which can promote tumor growth and spread.
- Researchers are testing small molecule inhibitors of CSF1R in clinical settings, both alone and with other treatments like immune checkpoint inhibitors, to improve cancer therapy.
- The study focuses on optimizing a potent bis-amide CSF1R inhibitor that has better stability and absorption in mice, making it a promising candidate for oral administration.
While enzalutamide and abiraterone are approved for treatment of metastatic castration-resistant prostate cancer (mCRPC), approximately 20-40% of patients have no response to these agents. It has been stipulated that the lack of response and the development of secondary resistance to these drugs may be due to the presence of AR splice variants. HDAC6 has a role in regulating the androgen receptor (AR) by modulating heat shock protein 90 (Hsp90) acetylation, which controls the nuclear localization and activation of the AR in androgen-dependent and independent scenarios.
View Article and Find Full Text PDF