Further evidence of biallelic NAV3 variants associated with recessive neurodevelopmental disorder with dysmorphism, developmental delay, intellectual disability, and behavioral abnormalities.

Neuron navigators (NAVs) are cytoskeleton-associated proteins well known for their role in axonal guidance, neuronal migration, and neurite growth necessary for neurodevelopment. Neuron navigator 3 (NAV3) is one of the three NAV proteins highly expressed in the embryonic and adult brain. However, the role of the NAV3 gene in human disease is not well-studied.

Using Virtual Care to Assess the Health Needs of People With Intellectual Disabilities: A Scoping Review.

Background: The COVID-19 pandemic precipitated a rapid roll-out of virtual health care services to people with intellectual disabilities. Limited evidence is available for clinicians to guide virtual care delivery.

Method: Twenty-three studies were identified through systematic searching of 16 databases.

Enhancing Anti-PD-1 Immunotherapy by Targeting MDSCs via Hepatic Arterial Infusion in Breast Cancer Liver Metastases.

Background: Surgery, chemotherapy, and radiation often have limited utility for advanced metastatic disease in the liver, and despite its promising activity in select cancers, PD-1 blockade therapy similarly has minimal benefit in this setting. Curaxin, CBL0137, is an experimental anti-cancer drug that disrupts the binding of DNA to histones, destabilizes chromatin, and induces Z-DNA formation which may stimulate anti-tumor immune responses.

Methods: Murine cell lines of colon (CT26) and breast (4T1) cancer were interrogated for survival and CBL0137-associated DNA changes in vitro.

Downstream effects of the pandemic? Spatiotemporal trends of quaternary ammonium compounds in suspended particulate matter of German rivers.

During the SARS-CoV-2 pandemic, the preventive use of antimicrobials such as quaternary ammonium compounds (QACs) surged worldwide. As cationic and surface-active biocides, QACs are only partly removed during wastewater treatment and may cause adverse ecological effects in the downstream environment. To understand the environmental consequences of increased disinfectant use during the pandemic, we investigated spatiotemporal QAC concentration trends in the suspended particulate matter (SPM) of three diverse German rivers.

Optimizing Titanium Carbide-Silver Oxide Nanostructures for Targeted Cancer Therapy: Synthesis, Functionalization, and In Vitro Evaluations.

Introduction  Cancer remains a significant health challenge, and nanoparticles (NPs) are promising candidates for cancer treatment due to their unique physicochemical properties and ability to selectively target tumour cells. Two-dimensional (2D) nanomaterials, such as MXenes, have attracted interest due to their electronic structures, optical properties, catalytic abilities, and exceptional physicochemical attributes. MXenes are highly suitable for surface functionalization or modification, and their unique properties make them promising candidates for various applications in the biological field.

Developing Augmented Pro-SOFA and Pro-SAPS Models by Integrating Biomarkers PCT, NLR, and CRP with SOFA and SAPS-III Scores.

Background: Sepsis, a life-threatening condition characterized by a dysregulated immune response to infection, remains a significant clinical challenge globally. This study aims to enhance the predictive accuracy of existing sepsis severity scores by developing augmented versions of the SOFA and SAPS-III models, termed Pro-SOFA and Pro-SAPS, through the integration of biomarkers procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP).

Methods: This prospective observational study was conducted in the medical ICU of a tertiary care hospital in southern India from August 2022 to December 2023.

An energy-efficient upconcentration of the bio-based carboxylic acids using multiple-effect evaporators.

This study proposes an integrated process chain to upconcentrate short-chain carboxylic acids (SCCA) like acetic, propionic, and butyric acid, produced from anaerobic fermentation of the organic fraction of municipal solid waste. The starting point is the residual biogas, which is produced from the anaerobic digestion of the solid fraction obtained after the acid fermentation. Using this biogas energy, integrated multiple-effect evaporator scenarios with varying SCCA initial concentrations from 10 to 40 g/L in the liquid fraction were simulated in Aspen Plus®.

Optimizing the Synthesis of Titanium Carbide-Bismuth Oxide for Enhanced Antimicrobial Properties.

Background The two-dimensional MXene, known as titanium carbide (Ti₃C₂), is characterized by its substantial interlayer spacing, extensive surface area, hydrophilic nature, exceptional thermal stability, and outstanding electrical conductivity. These distinctive attributes render Ti₃C₂ an ideal candidate for detecting target analytes and immobilizing biomolecules. Bismuth oxide (Bi₂O₃), an essential compound of bismuth, frequently acts as a foundational element in bismuth chemistry.

RIPK1 is essential for Herpes Simplex Virus-triggered ZBP1-dependent necroptosis in human cells.

Necroptosis initiated by the host sensor Z-NA Binding Protein-1 (ZBP1) is essential for host defense against a growing number of viruses, including Herpes Simplex Virus-1 (HSV-1). Studies with HSV-1 and other necroptogenic stimuli in murine settings have suggested that ZBP1 triggers necroptosis by directly complexing with the kinase RIPK3. Whether this is also the case in human cells, or whether additional co-factors are needed for ZBP1-mediated necroptosis, is unclear.

Whole genome sequence data of a lignocellulose-degrading bacterium, Arthrobacter koreensis BSB isolated from the soils of Santiniketan, India.

A draft genome sequence of an isolate of BSB from Santiniketan soil is being published. A. koreensis BSB produces lignocellulases, which are crucial in plant biomass degradation.

Emerging Two-Dimensional Ti3C2-BiOCl Nanoparticles for Excellent Antimicrobial and Antioxidant Properties.

Introduction  MXenes (TiC) represent a group of two-dimensional inorganic compounds, produced through a top-down exfoliation method. They comprise ultra-thin layers of transition metal carbides, or carbonitrides, and exhibit hydrophilic properties on their surfaces. Utilizing TiC BiOCl nanoparticles for their antimicrobial and antioxidant attributes involves enhancing synthesis, processing, and characterization techniques.

Letters to editor regarding the article "P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway".

We have read the original article titled "P4HA2 contributes to head and neck squamous carcinoma progression and EMT through PI3K/AKT signaling pathway" by Yan-Ling Wu et al., which was published in the Medical Oncology journal, with great interest. This study provides valuable insights into the involvement of P4HA2 in the progression of head and neck squamous cell carcinoma (HNSCC), highlighting its potential as an oncogenic factor that promotes epithelial-mesenchymal transition (EMT), motility, invasion, and proliferation of cancer cells through the PI3K/AKT signaling pathway.

Recent advancements in small interfering RNA based therapeutic approach on breast cancer.

Breast cancer (BC) is the most common and malignant tumor diagnosed in women, with 2.9 million cases in 2023 and the fifth highest cancer-causing mortality worldwide. Recent developments in targeted therapy options for BC have demonstrated the promising potential of small interfering RNA (siRNA)-based cancer therapeutic approaches.

Synthesis and Application of Titanium Carbide (Ti3C2)-Cobalt Sulfide (Co3S4) Nanocomposites in Amino Acid Biosensing.

Background The fabrication of titanium carbide (TiC)-cobalt sulfide (CoS)-based biosensors with high sensitivity and selectivity can change the biosensor manufacturing industry completely. Molecular and clinical diagnostics, disease progression monitoring, and drug discovery could utilize these sensors for early biomarker detection. MXene (TiC) is a two-dimensional material with exceptional electrical conductivity, hydrophilicity, great thermal stability, large interlayer spacing, and a high surface area.

Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives.

Colorectal cancer (CRC) is the main driver of fatality and the 3rd most often determined malignancy. Despite advances in detection and therapy, colorectal cancer (CRC) endures as the largest driver of cancer-related morbidity, and mortality. Modern habits and dietary negligence might be one of the reasons that have enhanced cancer prevalence.

Facile Fabrication of Titanium Carbide (Ti3C2)-Bismuth Vanadate (BiVO4) Nano-Coupled Oxides for Anti-cancer Activity.

Background MXene is a newly discovered substance consisting of 2D transition metal carbides or nitrides, produced through the disintegration and etching of aluminum layers. It possesses numerous properties, including a high surface area, conductivity, strength, stiffness, negative zeta potential, and excellent volumetric capacitance. MXene is utilized in detecting anti-cancer medicine, while bismuth vanadate (BiVO) is synthesized to form an optimized material for anti-cancer activity applications.

Graphene-Functionalized Titanium Carbide Synthesis and Characterization and Its Cytotoxic Effect on Cancer Cell Lines.

Background Graphene is a versatile material with promising applications in various fields such as electronics, energy, biomedicine, and the environment due to its exceptional mechanical strength, thermal and electrical conductivity, transparency, and chemical stability. Graphene has been extensively used in biological and medical settings. MXene is a two-dimensional (2D) material that exhibits a strong affinity for water and electrical conductivity because of its surface terminations (oxygen {-O}, fluorine {-F}, and hydroxyl {-OH}) and transition metal carbide or nitride.

Facile Synthesis of Silver Nanoparticles From Sustainable Sargassum sp. Seaweed Material and Its Anti-inflammatory Application.

Background Sustainable and environmentally friendly methods of producing nanoparticles are now being investigated by scientists. Because there are so many marine renewable resources, scientists are focusing their attention on studying seagrass, seaweed, mangroves, marine macroalgae, and microalgae. An exciting new frontier in research involves the synthesis of nanoparticles using extracts from seaweed.