Evaluating the impact of Xanthoparmelia conspersa extracts on signaling in HeLa cells and exploring their diverse biological activities.

Xanthoparmelia conspersa is rich in specific secondary metabolites but an unexplored lichen species. This work determined the chemical composition and biological activities (anti-microbial, anti-protozoal, and cytotoxic) of its methanolic and hexane extracts. Additionally, we evaluated the potential of these extracts in modulating cancer signaling pathways in HeLa cells.

An improved finite set model predictive control of SRM drive based on a voltage vectors strategy for low torque ripple.

The robust rotor structure and fault-tolerance characteristics of the Switched Reluctance Motors (SRMs) are the best choice for next-generation Electric Vehicle (EV) applications. This machine has few restraints like high torque and flux ripples. However, the existing Model Predictive Control (MPC) using multiple control objectives and maximum sectors in the switching table results in high torque ripples due to the improper sector partition, Voltage Vectors (VVs) and weight factor ( ) selection.

Multiobjective optimal power flow solutions using nondominated sorting colliding bodies optimization.

In the current work, an innovative nondominated sorting colliding bodies optimization (NSCBO) technique is introduced to tackle multiobjective optimal power flow (MOOPF) challenges within electrical power networks. This method offers a means to generate a diverse array of nondominated solutions in a single iteration by including the nondominated (ND) sorting process and the concept of crowding distance. Additionally, it utilizes a spread indicator to archive the latest nondominated solutions.

Advancement of electric vehicle technologies, classification of charging methodologies, and optimization strategies for sustainable development - A comprehensive review.

This comprehensive review covers the latest EV technologies, charging methods, and optimization strategies. Electric and hybrid vehicles are compared, explaining their operation and effects on energy, efficiency, and the environment. The review covers new EV charging technologies.

Optimal design of hybrid green energy powered reduced switch converter based shunt active power filter using horse herd algorithm.

Renewable energy sources are playing a leading role in today's world. However, integrating these sources into the distribution network through power electronic devices can lead to power quality (PQ) challenges. This work addresses PQ issues by utilizing a shunt active power filter in combination with an Energy Storage System (ESS), a Wind Energy Generation System (WEGS), and a Solar Energy System.

Effects of Different Agents of the Lubrication of i-gel Airway on the Incidence of Postoperative Sore Throat: A Prospective Randomised Controlled Trial.

Background And Aim: The aim of this study is to compare the effect of different lubricating agents used with the i-gel® laryngeal mask airway on the incidence of postoperative sore throat.

Materials And Methods: After obtaining institutional ethics approval, this prospective trial was conducted on 150 patients who were scheduled for minor surgical procedures. The study population was placed in three groups of 50 each, after randomization with computer-generated random numbers, based on the lubricant used (Group LJ: with lignocaine jelly as the lubricant, Group WJ: with water-based jelly as a lubricant, Group NS: with 0.

Experimental analysis of enhanced finite set model predictive control and direct torque control in SRM drives for torque ripple reduction.

The magnet-less switched reluctance motor (SRM) speed-torque characteristics are ideally suited for traction motor drive characteristics and its advantage to minimize the overall cost of on-road EVs. The main drawbacks are torque and flux ripple, which have produced high in low-speed operation. However, the emerging direct torque control (DTC) operated magnitude flux and torque estimation with voltage vectors (VVs) gives high torque ripples due to the selection of effective switching states and sector partition accuracy.

Ventral hernia repair in India: a Delphi consensus.

Purpose: While research on inguinal hernias is well-documented, ventral/incisional hernias still require investigation. In India, opinions on laparoscopic ventral hernia repair (LVHR) techniques are contested. The current consensus aims to standardize LVHR practice and identify gaps and unfulfilled demands that compromise patient safety and therapeutic outcomes.

A novel optimized neural network model for cyber attack detection using enhanced whale optimization algorithm.

Cybersecurity is critical in today's digitally linked and networked society. There is no way to overestimate the importance of cyber security as technology develops and becomes more pervasive in our daily lives. Cybersecurity is essential to people's protection.

Development of renewable energy fed three-level hybrid active filter for EV charging station load using Jaya grey wolf optimization.

This work develops a hybrid active power filter (HAPF) in this article to operate in conjunction with the energy storage system (ESS), wind power generation system (WPGS), and solar energy system (SES). It employs three level shunt voltage source converters (VSC) connected to the DC-bus. Optimization of the gain values of the fractional-order proportional integral derivative controller (FOPIDC) and parameter values of the HAPF is achieved using the Jaya grey wolf hybrid algorithm (GWJA).

Power enhancement in PV arrays under partial shaded conditions with different array configuration.

Solar Photovoltaic systems are used for electrical power generation, and they provide an alternative source to non-renewable energy sources like coal, oil, natural gas and nuclear energy. Photovoltaic arrays used in PV systems may be subjected to partial shading conditions, thereby affecting power generation because of higher power mismatch losses. Due to an uneven distribution of irradiation condition, some of the bypass diodes turned on and affect the power generation in a photovoltaic array.

Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Pers.

Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Pers. Earlier studies of machaeriol A () and B () did not show any affinity for cannabinoid receptor 1 (CB1 or CNR1), although they are structural analogs of psychoactive hexahydrocannabinol. This study comprehensively reports on the affinities of isolated Pers.

Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements.

Diverse inbred mouse strains are important biomedical research models, yet genome characterization of many strains is fundamentally lacking in comparison with humans. In particular, catalogs of structural variants (SVs) (variants ≥ 50 bp) are incomplete, limiting the discovery of causative alleles for phenotypic variation. Here, we resolve genome-wide SVs in 20 genetically distinct inbred mice with long-read sequencing.

Power enhanced solar PV array configuration based on calcudoku puzzle pattern for partial shaded PV system.

The power output of solar photovoltaic systems can be affected by environmental factors, such as partial shading. This can lead to a decrease in the power conversion rate of the system. Although existing solutions for this issue are cost-effective and efficient, new solutions could further improve the system's performance by increasing consistency, power generation, and reducing mismatch loss and costs.

The Oligostilbene Gnetin H Is a Novel Glycolysis Inhibitor That Regulates Thioredoxin Interacting Protein Expression and Synergizes with OXPHOS Inhibitor in Cancer Cells.

Since aerobic glycolysis was first observed in tumors almost a century ago by Otto Warburg, the field of cancer cell metabolism has sparked the interest of scientists around the world as it might offer new avenues of treatment for malignant cells. Our current study claims the discovery of gnetin H (GH) as a novel glycolysis inhibitor that can decrease metabolic activity and lactic acid synthesis and displays a strong cytostatic effect in melanoma and glioblastoma cells. Compared to most of the other glycolysis inhibitors used in combination with the complex-1 mitochondrial inhibitor phenformin (Phen), GH more potently inhibited cell growth.

Solar photovoltaic converter controller using opposition-based reinforcement learning with butterfly optimization algorithm under partial shading conditions.

The major use of a power point tracking controller is to maximize or enhance the power generation in photovoltaic systems. These systems are steered to operate and maximize the power point. Under partial shading conditions, the power points may vary or fluctuate between global maxima and local maxima.

Inhibits Cancer Proliferation in Signaling Pathways of 12 Reporter Genes.

This study aimed to examine if methanolic extracts of Mill. can inhibit HeLa cell proliferation through the modulation of cancer-related signaling pathways. The cytotoxicity and chemical composition of leaves and root extracts were also determined.

Transposable element-mediated rearrangements are prevalent in human genomes.

Transposable elements constitute about half of human genomes, and their role in generating human variation through retrotransposition is broadly studied and appreciated. Structural variants mediated by transposons, which we call transposable element-mediated rearrangements (TEMRs), are less well studied, and the mechanisms leading to their formation as well as their broader impact on human diversity are poorly understood. Here, we identify 493 unique TEMRs across the genomes of three individuals.

Hernia Sac Preservation for Prevention of Transversus Abdominis Release in Laparoscopic Extended-Totally Extra Peritoneal Repair of Ventral Hernia: A Minimalistic Solution for a Formidable Challenge.

Ventral hernia repair has always been an extensive and challenging surgery. The laparoscopic extended-Totally Extraperitoneal (E-TEP) technique of ventral hernia repair is gaining popularity due to the advantage of placing a large mesh in the retro rectus plane. When done through a Laparoscopic approach, the difficulty of the procedure is compounded by multiple factors such as obtaining retro muscular access, maintaining the retro muscular plane, crossing over to the contralateral retro muscular plane without entering intraperitoneally, suturing in a limited space, and manipulation of a large mesh in a constricted space for placement.

Piloting a Survey-Based Assessment of Transparency and Trustworthiness with Three Medical AI Tools.

Artificial intelligence (AI) offers the potential to support healthcare delivery, but poorly trained or validated algorithms bear risks of harm. Ethical guidelines stated transparency about model development and validation as a requirement for trustworthy AI. Abundant guidance exists to provide transparency through reporting, but poorly reported medical AI tools are common.