[An alternative approach to the surgical correction on malpositions of the uterus].

Endosurgical correction of the uterus was carried out in 57 patients. Indications for surgery were improper positions of the uterus-retroversio, retrodeviatio uteri, excessive mobility of the uterus, and complaints of heaviness at the bottom of the abdomen, leukorrhea, pain of different type in the lower portions of the abdomen, profuse and long menses, dyspareunic pain upon deep penetration, reduced libido, a sensation of a foreign body in the vaginal cleft, urine incontinence upon strain. The mean age of the patients was 35 +/- 3 years.

[Diagnosis of internal endometriosis of the uterus].

The authors analyze the informative value of instrumental methods of examination (hysteroscopy, hysterosalpingography, ultrasonic scanning) and measurements of blood phosphatidyl inosites in 50 patients with internal endometriosis and come to a conclusion that it is in proportion with the disease severity, hysteroscopy being the most informative. A reliable reduction (p < 0.001) of blood phosphatidyl inosites were seen in endometriosis patients as against normal subjects.

[Changes in the contents of phosphoinositides in formed elements of blood and endometrial tissue in patients with hyperplastic processes and cancer of the endometrium].

The levels of phosphoinositides were measured in blood macrophages, platelets, lymphocytes, granulocytes, neutrophils, and red cells, as well as in endometrial tissue of 175 patients with glandular hyperplasia of the endometrium, atypical hyperplasia, endometrial polyps and cancer. A reliable reduction of the content of phosphatidyl inositides and phosphatidyl inositide-S-phosphates was observed in all formed elements of the blood, the most marked decrease being observed in endometrial cancer. On the contrary, the content of phosphatidyl inositide-4-phosphates and phosphatidyl inositide-4.

[Change in phospholipid content in platelets, immunocompetent cells and myometrial tissue in patients with internal endometriosis].

A method of flow horizontal chromatography has been developed permitting investigation of blood and tissue cellular phospholipids ruling out lipid peroxidation effects on cellular membranes. Phospholipid levels of blood and myometrial tissue cells were measured by this method in 67 patients with histologically verified internal endometriosis. Phospholipid and phosphatidyl inosite levels in platelets and immunocompetent cells of these patients reliably differed from those in healthy women.

[A clinico-morphological comparison of the ultrasonic criteria of adenomyosis].

The authors analyze the data of ultrasonic examinations in 110 patients operated on for adenomyosis and in 50 patients with this condition not exposed to surgery, in whom the diagnosis was made after comprehensive examinations. The accuracy of ultrasonic diagnosis correlated with the disease severity. Diagnostic difficulties are explained by the absence of pathognomonic echographic criteria, frequent associations with myoma, and with false echo signals emerging in the myometrium.

[The dynamics of the rapid changes in the phospholipids of the whole blood and blood cells in patients with endometriosis interna].

Time course of rapid changes in blood phospholipids and blood cells was studied in 44 patients with endometriosis. Rapid reversible blood phospholipid changes were observed when these patients' red cells and lymphocytes were incubated with calcium chloride. Time course of rapid changes in phosphoinosites, sphyngomyelines, phosphatidylserines, phosphlatidylethanolamines of patients' red and white blood cells, whole blood, and myometrial tissue differed significantly from that in healthy women.

[New data on the pathogenesis of endometriosis interna].

Eighty-six patients with histologically verified internal endometriosis were examined using histochemical, morphometric methods, and measurements of blood and myometrial tissue phosphatidyl inosites. Blood levels of phosphatidyl inosites were found reliably decreased in the patients vs. normal subjects, whereas their levels in myometrial tissue were significantly increased.

[The clinical picture, diagnosis and treatment of the corpus-isthmus location of uterine endometriosis interna].

The authors analyze the results of comprehensive examinations and treatment of 79 patients with corporal isthmic adenomyosis. Comprehensive examinations making use of clinical, instrumental (hysteroscopy, hysterosalpingography, echography), biochemical (measurements of blood and myometrial phosphatidylinosites), and morphologic methods are needed for a reliable diagnosis of this condition. Blood phosphatidylinosite measurements may be used as an objective test to assess the efficacy of hormonal therapy.

[Dynamics of lysozyme levels in the blood serum and milk of puerperae with various functional activities of the breasts].

The morbidity rates, ++features of lactation formation, and serum and breast milk lysozyme levels were studied in 91 parturients who showed various breast functional activity in the early postpartum period. The highest frequency of postpartum ++pyo-septic diseases was found in females with hyperlactation. There was earlier appearance of foremilk and milk in these females.

[Status of the gonadotropic function of the pituitary gland in the late periods after induced abortion in the first trimester of pregnancy].

Follicle-stimulating, luteinizing hormone and prolactin secretion has been evaluated with a radioimmunoassay at less than or equal to 5 years following a first-trimester abortion. Pituitary prolactin secretion was found to be most affected by abortion (96% of observations).

[State of the autonomic nervous system after induced abortion in the lst trimester].

The autonomic nervous system has been examined in 271 patients with a history of first-trimester induced abortion. It was ascertained that induced abortion affected the autonomic nervous system, thus impairing adaptive potentials and entailing the onset or aggravation of preexisting autonomic vascular dystonia.

[Endogenous opioid system in the realization of the analgesic effect of alpha-tocopherol in reference to algomenorrhea].

Beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). There was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. Naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain.