Publications by authors named "Bakulesh M Khamar"
Precise regulation of inflammasome is critical during any pathogenic encounter. The whole innate immune system comprising of pattern recognition receptors (PRRs) relies on its ability to sense microbes. The fate of cellular death in infected cells depends mostly on the activation of these inflammasome, the dysregulation of which, due to functional manipulation by various pathogens, leads to be the cause of many human diseases.
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- - Visceral leishmaniasis, a severe and fatal disease, is caused by a parasite that evades the immune system by manipulating immune responses, particularly through a protein called BLIMP-1.
- - The study reveals that BLIMP-1 suppresses the death of immune cells (macrophage pyroptosis) during infection, impacting the NFκβ-NLRP3 signaling pathway, which is essential for an effective immune response.
- - Experiments demonstrate an inverse relationship between BLIMP-1 and NFκβ, suggesting that the parasite exploits this mechanism to hinder cell death and promote its survival in the host.
Significant advances have been made in understanding the regulation of inflammasomes and its involvement in innate immunity during pathogenic infections. Inflammasome activation is a tightly regulated process that provides defense against pathogenic infection and important for inflammatory response. Very few studies on the involvement of NLRP3 inflammasome protein complex have been reported in leishmanial infections with contradictory results and without much mechanistic insights.
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