Combined In Silico and Experimental Investigations of Resveratrol Encapsulation by Beta-Cyclodextrin.

The results of the computational and the physicochemical studies of the encapsulation of resveratrol with β-cyclodextrin are presented here. At first, the molecular docking experiments predicted good binding. Several MD simulations and MM-PBSA experiments confirmed the reliable binding, showing optimal kinetics and energy.

Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia.

Materials And Methods: 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia.

Obtaining and Investigation of the -Cyclodextrin Inclusion Complex with Vitamin Oil Solution.

. The research results of fat-soluble vitamin (cholecalciferol) encapsulation with -cyclodextrin have been presented in this work. The vitamin inclusion complex with -cyclodextrin was obtained under microwave radiation.

The Oxidized proteins and activity of the Cl-/HCО3- exchanger in erythrocytes of patients with acute alcohol intoxication.

Background: The purpose of this research was to study the morphological properties and the products of oxidative protein modification in erythrocytes of patients with acute alcohol intoxication. Two groups of subjects were analyzed. The first one included 39 patients with acute alcohol intoxication.

The Levels of Hepcidin and Erythropoietin in Pregnant Women with Anemia of Various Geneses.

Aim: The purpose of the present research was to study the content of erythropoietin and hepcidin in serum in pregnant women with iron deficiency anaemia and anaemia of chronic inflammation.

Methods: The authors examined 98 pregnant women who were observed in LLP (Regional obstetric-gynaecological centre) in Karaganda. The including criteria for pregnant women in the study was the informed consent of the woman to participate in the study.

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer.

Background: According to several authors, neutrophil extracellular traps (NETs) play an important role in the mechanisms of cancer development and metastatic processes, which allows them to be considered as a potential new target for the treatment of cancer.

Aim: To investigate the presence of extracellular neutrophil traps in the blood of patients with cervical cancer on the background of the combined treatment.

Materials And Methods: The study was conducted in 28 patients with cervical cancer.

Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity.

Background: At the present time the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in the development and progression of community-acquired pneumonia (CAP). However the nature and direction of the oxidative protein changes in CAP patient's blood had been almost unexplored.

Aim: To define oxidative and modified proteins in erythrocytes and blood plasma of CAP patients.

[Characteristics of oxidative metabolism parameters at acute intoxication induced by surrogate alcohol].

The aim of this study was to estimate the oxidative metabolism parameters in blood of patients with acute intoxication of different severity induced by surrogate alcohol. The study involved 30 people (26-40 years old) with a diagnosis of acute intoxication induced by surrogate alcohol. Two groups of patients were formed.

The modified proteins in erythrocytes and regulation of erythrocytes volume in patients with chronic kidney disease.

Objective: The role of oxidatively modified proteins in progression of chronic kidney disease has been discussed. We have got the results demonstrating the alteration of band 3 protein activity in erythrocytes of patients with chronic kidney disease. We presumed that it might be associated with oxidative damage of intracellular proteins.

Myeloperoxidase activity and the oxidized proteins in blood neutrophils of patients with pneumonia.

The main purpose of our investigation was to study myeloperoxidase activity and concentration of oxidized proteins in blood neutrophils of patients with ambulant pneumonia and secondary pneumonia which has arisen on a background of chronic obstructive pulmonary disease (COPD). Patients were divided into 2 groups. 17 patients with ambulant pneumonia moderate severity and respiratory insufficiency of grade 2 were included in the 1-st group.

[Physical and chemical markers of chronic obstructive lung disease development in industrial workers].

The article demonstrates that patients with chronic obstructive lung disease (COLD) of both mixed and bronchitis forms with medium severity grade appeared to have 2 types of changes in morphologic types of serum faces. Patients with various clinical forms of severe COLD presented unidirectional change in morphologic types of serum faces. Patients with various forms of moderate COLD had one variant of morphologic types of serum faces was close to that in the patients with more severe clinical course--so that face can be considered as a "transitional form" between moderate and severe COLD.

[Innovative educational technology in the teaching of propaedeutic of internal diseases].

This article presents analysis of the results of inculcation of innovative learning technologies in teaching on propaedeutic of internal diseases which is first clinical discipline faced by medical students of the University. Credit-modular training included integration of propaedeutic of internal diseases with basic disciplines of the third year (the normal anatomy, physiology, pathological anatomy, histology, pathophysiology, visual diagnostics and pharmacology). There are 8 models on following systems: respiratory, cardiovascular, musculoskeletal, endocrine, urogenital, hematopoietic, nervous, digestive.

[Research of anti-inflammatory activity of the thiosemicarbaziden-morpholinilacetic acid].

Studying of synthesis and anti-inflammatory activity of a number of new derivatives of N-acylsubstituted of thiosemicarbazide and product of their heterocyclization (thiadiazole). In work the following reagents are used: hydrazide of N-morfolinilacetic acids, allil-, benzoil-, 4-brom-benzoil isothiocyanates. IR spectrums of compounds are removed on a spectrometer from Fourier converter by "AVATAR-320" in tablets with KBr, 1H NMR spectra were recorded on Bruker DRX500 spectrometer with a frequency of 500 MHz in DMSO-d6 solution relative to internal tetramethylsilane standard.

[Cardiovascular diseases in the population of industrial towns and environmental factors].

Aim: To study the influence of environmental factors (EFs) on the development of cardiovascular diseases in the population of industrial towns of the Republic of Kazakhstan.

Subjects And Methods: The investigation covered an 18-59-year-old adult population who had been living in the urbanized areas of the Republic of Kazakhstan for at least 10 years, who worked in harmless conditions and were unregistered as having chronic diseases. At Stage 1, screening (a therapist's examination, blood general and immunological tests, and electrocardiography) was carried out for risk group persons who underwent in-depth clinical examination (blood biochemical test) at Stage 2.

[The study of quality characteristics of the hydrogel ointments and films based on copolymers divinyl esters of diethylene glycol].

The possibility of using a hydrogel based on divinyl ether co- and terpolymer of diethylene glycol as the backbone polymer for incorporating water-soluble medicinal substances was examined. The character of the influence of emulsifiers, plasticizers, high-boiling liquids and bioactive substances is defined within the changes of physical-chemical properties of obtained hydrogels. The obtained polyelectrolyte hydrogels by their homogeneity, dehydration and rheological characteristics may be of concern in function of matrices to create external prolonged-action dosage forms.

[Cellular immunity state assessed in bronchial and alveolar lavage for experimental animals exposed to the rubber dust].

Experiments on 21 rats helped to study influence of mechanical rubber dust on cellular immunity state in bronchial and alveolar lavage, efficiency of Ruvimine for prophylaxis. Findings are that mechanical rubber dust is strongly cytotoxic. Ruvimine administration during the whole experiment demonstrates therapeutic and prophylactic effect and normalizes local pulmonary phagocytosis.