[The role of structural changes of the endothelium and myocardium in the development of experimental heart failure].

The aim of the investigation was to study the role of structural myocardial and endothelial reorganization during the experimental heart failure (doxorubicin model). Rat endocardial and aortal endothelium as well as left ventricular myocardium, were studied using the methods of light and electron microscopy and immunocytochemistry (TUNEL-assay). The major regularities of structural and functional myocardial and endothelial reorganization were determined in rats with an experimental heart failure.

[Effects of endotheline and nitric oxide on vascular tonicity in patients with chronic cardiac failure].

Aim: To examine effects of endotheline-1 (ET-1) and nitric oxide (NO) on endothelium-dependent mechanisms of vascular tonicity regulation in patients with chronic cardiac failure (CCF) of FC I-IV (NYHA).

Material And Methods: Vascular reactions of 94 patients with CCF of FC I-IV were examined according to D.S.