Background: Allograft loss is the most feared outcome of kidney transplant recipients. We aimed to develop a dynamic Bayesian model using estimated glomerular filtration rate (eGFR) trajectories to predict long-term allograft and patient survivals.
Methods: We used data from the Australian and New Zealand Dialysis and Transplant registry and included all adult kidney transplant recipients (1980-2017) in Australia (derivation cohort) and New Zealand (NZ, validation cohort).
Ocimum species have a great interest in different traditional medicinal systems. This study examined the chemical composition, antioxidant properties, enzyme inhibitory effects, and antibacterial and antifungal activities of the aerial parts of Ocimum gratissimum, Ocimum americanum, and Ocimum basilicum from the Comoros Islands. The extracts were analyzed using high-performance liquid chromatography-mass spectrometry (HPLC-MS) to determine their chemical composition.
View Article and Find Full Text PDFObjectives: The prevalence of low birth weight (LBW) is an important indicator of child health and wellbeing. However, in many countries, decisions regarding care and treatment are often based on mothers' perceptions of their children's birth size due to a lack of objective birth weight data. Additionally, birth weight data that is self-reported or recorded often encounters the issue of heaping.
View Article and Find Full Text PDFBackground: Asthma is the most common chronic respiratory illness among children in Australia. While childhood asthma prevalence varies by region, little is known about variations at the small geographic area level. Identifying small geographic area variations in asthma is critical for highlighting hotspots for targeted interventions.
View Article and Find Full Text PDFThe fouling phenomenon grabbed global attention and caused huge economic losses specifically in marine-related industries. Sessile behavior exposed the sponge to the risk of fouling. However, their bodies remained free from foulers, which were attributed to the chemical defense system.
View Article and Find Full Text PDFThe proliferation of the Internet of Things (IoT) devices has led to a surge in Internet traffic characterized by variabilities in Quality of Service (QoS) demands. Managing these devices and traffic effectively proves challenging, particularly within conventional IoT network architectures lacking centralized management. However, the advent of Software-Defined Networking (SDN) presents intriguing opportunities for network management, capable of addressing challenges in traditional IoT architectures.
View Article and Find Full Text PDFThis present study aimed to investigate the effects of (Red seaweed) extract and its fraction on scavenger receptor class B type I () gene expressions. studies of the activity of extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of showed the highest expression levels of the gene luciferase assay and increased expression compared to the negative control.
View Article and Find Full Text PDFSoftware-defined networking (SDN) is a networking architecture with improved efficiency achieved by moving networking decisions from the data plane to provide them critically at the control plane. In a traditional SDN, typically, a single controller is used. However, the complexity of modern networks due to their size and high traffic volume with varied quality of service requirements have introduced high control message communications overhead on the controller.
View Article and Find Full Text PDFOdanacatib (ODN) is a selective cathepsin K inhibitor that acts as an anti-resorptive agent to treat osteoporosis. ODN is also found effective in reducing the effect of severe periodontitis. The interaction between ODN and human serum albumin (HSA) was investigated using spectroscopic, microscopic, and in silico approaches to characterize their binding.
View Article and Find Full Text PDFIn the present study, we performed comprehensive LC-MS chemical profiling and biological tests of leaves and stem bark extracts of different polarities. In total, 60 bioactive compounds were tentatively identified in all extracts. The 80% ethanolic stem bark extract exhibited the highest activity in the ABTS assay, equal to 551.
View Article and Find Full Text PDFTexture is an important sensory attribute for overall quality and consumer acceptance of prawns. However, texture is affected during cold storage due to the proteolytic activity of endogenous proteases, resulting in poor quality and a short shelf life. The objective of this study is to determine the inhibitory effects of leaves extract (AMLE) (0, 3, 10 and 20%) on the trypsin, cathepsin B and collagenase activities extracted from the cephalothorax of .
View Article and Find Full Text PDFUrbanization is accelerating in developing countries, which are simultaneously experiencing a rise in the prevalence of overnutrition (i.e., overweight and obesity), specifically among women.
View Article and Find Full Text PDFBiofouling is defined as the excessive colonization process of epibiotic organisms, ranging from microfoulers to macrofoulers, on any submerged surface in water. Previous research has attempted to explore the antifouling activity of bacterial isolates due to the biofouling problems occurring worldwide. One solution is to inhibit the early stage of fouling using secondary metabolites produced by marine bacteria.
View Article and Find Full Text PDFBackground: The PedsQL 3.0 End Stage Renal Disease (ESRD) Module is a well-accepted instrument internationally but it is not available in the local language. We aimed to validate the Bahasa Melayu (Malay language) version and determine the health-related quality of life (HRQoL) scores amongst children with CKD in Malaysia.
View Article and Find Full Text PDFIn this study, phytochemical and pharmacological screening of the aerial part and roots extracts from Doronicum orientale Hoffm. (Asteraceae) was carried out. Plant extracts were obtained using solvents of different polarity (hexane, ethyl acetate, ethanol, ethanol/water, water) for selection the most optimal solvent for the extraction of active compounds.
View Article and Find Full Text PDFTechnology is evolving rapidly around the world, and the use of mobile devices is increasing every day. Today, everyone owns a mobile device, including young children. Parents provide and allow young children to use mobile devices for various purposes.
View Article and Find Full Text PDFGiant freshwater prawn ( is one of the important aquaculture species and quickly expanding in many countries. High demand and mass commercialization on regulating 18% of the international seafood business. Seafood products contend with various level across the supply chains and time to reach the consumers depending upon the marketing and delivery channels after harvesting.
View Article and Find Full Text PDFThalassemia is the commonest hemoglobinopathy in Southeast Asia. Kidney dysfunction is an underreported sequelae in children with thalassemia. We conducted a retrospective study to identify the prevalence of and predisposing factors for kidney dysfunction in children with transfusion-dependent thalassemia (TDT).
View Article and Find Full Text PDFThe internet of reality or augmented reality has been considered a breakthrough and an outstanding critical mutation with an emphasis on data mining leading to dismantling of some of its assumptions among several of its stakeholders. In this work, we study the pillars of these technologies connected to web usage as the Internet of things (IoT) system's healthcare infrastructure. We used several data mining techniques to evaluate the online advertisement data set, which can be categorized as high dimensional with 1,553 attributes, and the imbalanced data set, which automatically simulates an IoT discrimination problem.
View Article and Find Full Text PDFUnlabelled: Cancer is an uncontrolled multiplication of cells. The desire efficacy and severe toxicity of current anticancer drugs urge exploring and investigating a better alternative to existing chemotherapeutics. Natural products of marine origin are excellent sources of potential new drugs of enhanced biological activities.
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