[Experimental study of combined effects of benzo(a)pyrene and ortho-cresol on the body].

Ortho-cresol (o-cresol) produces a modifying influence on the effect produced by benz/a/pyrene (BP) under mice CC57B exposure to the combined peroral administration of the two chemicals. A low-toxic dose of o-cresol (Img) abruptly activates the effect of the same dose of BP (1 mg) according to all parameters (increase of the frequency, coefficient of multiplicity and degree of malignancy of tumours, shortening of the latency period) and somewhat inhibits its activity when administered before or after BP. Simultaneous administration of o-cresol in a ++super-toxic dose (10 mg) and BP in an optimal dose (5 mg) does not change the frequency of tumours, as compared to the control, however, inhibits the progression of induces neoplasms, which is manifest in the decrease of the frequency of malignancy, multiplicity of appearance and lengthening of the time of the onset of their malignization.

[The modifying effect of ortho-cresol on benzo(a)pyrene-induced carcinogenesis in mice].

A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (B(a)P) in their combined peroral administration to CC57Br mice has been revealed. During the simultaneous administration of the o-cresol (1 mg) and B(a)P (1 mg) the rate of tumours, their multiplicity index, the degree of malignancy increased and the latent period shortened. In case of o-cresol administration before or after B(a)P (in the same doses) the decrease of carcinogenic effect has been revealed.