Publications by authors named "Bajana I"
Article Synopsis
- - The text discusses the need to identify specific subgroups of sepsis patients who might benefit from targeted treatments, known as rescue therapies, even while all patients receive standard care.
- - It highlights the classification of sepsis into various phenotypes, which are based on differing immune responses, such as hyperinflammatory or immunosuppressive states, suggesting that each may require tailored therapies for better outcomes.
- - The concept of precision medicine is emphasized, aiming to customize treatments according to the unique characteristics and mechanisms of sepsis in individual patients, focusing on developing targeted interventions.
Article Synopsis
- Streptococcal toxic shock syndrome (STTS) is a severe medical emergency characterized by rapid symptom onset and high risks of morbidity and mortality, highlighting the need for quick recognition and intervention.
- A study observed 13 patients at Vall d'Hebron University Hospital with invasive infections, primarily community-acquired pneumonia and skin infections, all receiving immediate antibiotic treatment and various organ support therapies.
- The research identified three patient phenotypes (hyperinflammatory, low perfusion, hypogammaglobulinemic) that could help tailor personalized treatments, stressing the importance of combining rapid antibiotics and strategic source control to improve survival outcomes.
Objectives: To determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.
Design: Prospective, observational, single-center study.
Setting: Intensive Care Unit (ICU), Vall d'Hebron University Hospital, Barcelona.
Article Synopsis
- - The study aims to find new protein biomarkers for early diagnosis of sepsis and to understand their connection to organ dysfunction and mortality using advanced omics techniques.
- - Researchers analyzed plasma proteins from 141 adult sepsis patients using mass spectrometry, identifying 177 proteins and establishing that nine are linked to organ dysfunction and twenty-two are associated with mortality.
- - Results show these biomarkers have high accuracy and reliability, suggesting that specific protein patterns can indicate serious outcomes in sepsis patients.
Article Synopsis
- This case report discusses a patient with Hemophagocytic lymphohistiocytosis (HLH) triggered by NK-type non-Hodgkin lymphoma and Epstein-Barr virus, leading to severe organ dysfunction and shock.
- Comprehensive diagnostic tests, including a liver biopsy and bone marrow aspirate, confirmed the HLH diagnosis, and the patient met the HLH-2004 criteria.
- Treatment included corticosteroids and etoposide, along with cytokine hemoadsorption, which dramatically improved the patient's hemodynamics and reduced the need for vasopressive medications.
Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report.
Mult Scler Relat Disord
May 2020
Background: Alemtuzumab is a monoclonal antibody targeting CD-52, used for treating relapsing-remitting multiple sclerosis (RRMS).
Methods: We present a case of a 44-year-old male with RRMS who was admitted due to fever and jaundice after starting treatment with alemtuzumab 12 months ago.
Results: He was diagnosed with hemophagocytic syndrome (HS).