Publications by authors named "Bajaj Rani"
Emerging Functions of Actins and Actin Binding Proteins in Trypanosomatids.
Front Cell Dev Biol
October 2020
Article Synopsis
- Actin is a crucial protein in the cytoskeleton of trypanosomatids, with at least ten different actin binding proteins identified in three major organisms of this class.
- Research has characterized specific actins and their binding partners, revealing important roles in regulating endocytosis and intracellular trafficking.
- Significant findings include actin1's diverse locations and functions, including binding to DNA, and the roles of specific myosins and twinfilin in cellular processes like spindle elongation and flagellum dynamics.
Article Synopsis
- Myosin XXI (Myo21) is a crucial protein in kinetoplastid parasites like Leishmania, playing a key role in flagellum assembly, cell motility, and vesicle transport.
- Experiments using green fluorescent protein (GFP) constructs of Myo21 showed that removing one or both ubiquitin associated (UBA)-like domains (UBLDs) impairs the protein's ability to localize and function properly in the flagellum, resulting in shorter flagella and slower motility.
- The deletion of both UBLDs negatively impacted intracellular vesicle transport and cell growth, predominantly due to issues during cell division, indicating that UBLDs are essential for the proper functioning of Myo21
Objectives: ESBL-producing isolates of the Enterobacteriaceae occur throughout the world. The objectives of this study were to characterize uropathogenic Escherichia coli isolated at a tertiary care hospital in southern India, and shed light on bla sequences of Indian origin.
Results: A cohort of 13 urinary isolates of E.
Catharanthus roseus [L.] is a major source of the monoterpene indole alkaloids (MIAs), which are of significant interest due to their therapeutic value. These molecules are formed through an intermediate, cis-trans-nepetalactol, a cyclized product of 10-oxogeranial.
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