Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis.

Bone and joint tuberculosis (BJTB), caused by Mycobacterium tuberculosis (MTB), is a prevalent form of extrapulmonary tuberculosis that poses significant challenges to global public health due to difficulties in early diagnosis, prolonged treatment cycles, and drug resistance. Recent advancements in nanotechnology have introduced novel solutions for the early detection and precise treatment of BJTB, leveraging unique physicochemical properties such as high specific surface area, targeted delivery capabilities, sustained drug release, and excellent biocompatibility. In diagnostic applications, nanomaterials markedly enhance the sensitivity and accuracy of detection methods while reducing testing time.

Mental health literacy and its relationship with health-promoting behaviors of community-dwelling older adults: A latent profile analysis.

Objectives: To explore the latent profiles of mental health literacy among community-dwelling older adults and analyze their relationship with health-promoting behaviors.

Methods: A cross-sectional study was conducted among 321 community-dwelling older adults using a general information questionnaire, the Chinese version of the Mental Health Literacy Scale, and the Geriatric Health Promotion Scale. A latent profile analysis was performed to identify latent profiles of mental health literacy among community-dwelling older adults.

The MdCBF1/2-MdTST1/2 module regulates sugar accumulation in response to low temperature in apple.

Soluble sugar content is a key component in controlling fruit flavor, and its accumulation in fruit is largely determined by sugar metabolism and transportation. When the diurnal temperature range is greater, the fleshy fruits accumulated more soluble sugars and become more sweeter. However, the molecular mechanism underlying this response remains largely unknown.

Biodegradation of Imazethapyr by Bacterial Strain IM9601 Isolated from Agricultural Soil.

The widespread utilization of the herbicide imazethapyr presents significant challenges to crop rotation and results in detrimental soil degradation issues. Bacterial biodegradation has emerged as a promising and eco-friendly approach for mitigating pesticide residues contamination in the environment. In this study, a novel bacterium, identified as Brevibacterium sp.

The SnRK2.3-AREB1-TST1/2 cascade activated by cytosolic glucose regulates sugar accumulation across tonoplasts in apple and tomato.

Soluble sugars are the core components of fruit quality, and the degree of sugar accumulation is largely determined by tonoplast-localized sugar transporters. We previously showed that two classes of tonoplast sugar transporters, MdERDL6 and MdTST1/2, coordinately regulate sugar accumulation in vacuoles. However, the mechanism underlying this coordination remains unknown.

Transcriptome Profiling and Identification of the Candidate Genes Involved in Early Ripening in .

The early ripening jujube is an immensely popular fresh fruit due to its high commercial value as well as rich nutrition. However, little is known about the mechanism of jujube fruit's ripening. In this study, the transcriptome profiles were comprehensively analyzed between the 'Lingwu Changzao' jujube and its early-ripening mutant during the fruit development and maturity.

F-box protein MdAMR1L1 regulates ascorbate biosynthesis in apple by modulating GDP-mannose pyrophosphorylase.

Ascorbate (Asc) is an important antioxidant in plants and humans that plays key roles in various physiological processes. Understanding the regulation of Asc content in fruit plants is important for improving plant resiliency and optimizing Asc in food. Here, we found that both the transcript level and protein abundance of Asc Mannose pathway Regulator 1 Like 1 (MdAMR1L1) was negatively associated with Asc levels during the development of apple (Malus × domestica) fruit.

CircRNA casein kinase 1 gamma 1 (circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1 (MAPK1).

Background: The initiation and development of thyroid cancer may be associated with the deregulation of circular RNAs (circRNAs). The purpose of this work was to explore the role of circRNA casein kinase 1 gamma 1 (circ-CSNK1G1) in thyroid cancer.

Methods: The expression of circ-CSNK1G1, miR-149-5p, and mitogen-activated protein kinase 1 (MAPK1) was concluded using quantitative real-time PCR (qPCR), and the expression of MAPK1 protein was detected by Western blot assay.

Factors Influencing the Hydration, Dimensional Stability, and Strength Development of the OPC-CSA-Anhydrite Ternary System.

Due to the advantages of high early strength and rapid setting, ternary systems consisting of ordinary Portland clinker (OPC), calcium sulphoaluminate (CSA) clinker, and anhydrite have broad application prospects. However, further studies need to be undertaken to find a more optimal mixing proportion of this ternary binder in order to meet basic performance requirements. In this paper, isothermal calorimetric tests, chemical shrinkage tests, drying shrinkage tests, and compressive strength tests were carried out to systematically identify the effect of the OPC/CSA ratio and anhydrite dosage on the hydration, mechanical property development, and dimensional stability of ternary binders.

Combined Profiling of Transcriptome and DNA Methylome Reveal Genes Involved in Accumulation of Soluble Sugars and Organic Acid in Apple Fruits.

Organic acids and soluble sugars are the major determinants of fruit organoleptic quality. Additionally, DNA methylation has crucial regulatory effects on various processes. However, the epigenetic modifications in the regulation of organic acid and soluble sugar accumulation in apple fruits remain uncharacterized.

Nitrogen Levels Regulate Sugar Metabolism and Transport in the Shoot Tips of Crabapple Plants.

To comprehensively understand the responses of carbohydrate metabolism and transport to different levels of nitrogen supply in growing shoot tips of crabapple ( Rehd), enzyme activities and related genes involved in the sugar metabolism pathway were investigated. The nitrogen and chlorophyll content of plants increased with increasing nitrogen supply. High nitrogen application increased the net photosynthesis rate and the growth rate of shoot tips but decreased the synthesis capability of sucrose and sorbitol in mature leaves.

MdERDL6-mediated glucose efflux to the cytosol promotes sugar accumulation in the vacuole through up-regulating TSTs in apple and tomato.

Sugar transport across tonoplasts is essential for maintaining cellular sugar homeostasis and metabolic balance in plant cells. It remains unclear, however, how this process is regulated among different classes of sugar transporters. Here, we identified a tonoplast H/glucose symporter, MdERDL6-1, from apples, which was highly expressed in fruits and exhibited expression patterns similar to those of the tonoplast H/sugar antiporters MdTST1 and MdTST2.

Stripped Electrode Based Electrowetting-on-Dielectric Digital Microfluidics for Precise and Controllable Parallel Microdrop Generation.

Microdrop generation with excellent controllability and volume precision is of paramount significance for a large variety of microfluidic applications. In this work, we propose a new configuration comprising only stripped electrodes of rectangular shape for the closed electrowetting-on-dielectric digital microfluidic (EWOD DMF) system and investigate its parallel microdrop generation outcomes via a numerical approach. The microfluidic droplet motion is solved by a finite-volume scheme on a fixed computational domain.

Complete Genome Sequence of Pseudomonas syringae pv. lapsa Strain ATCC 10859, Isolated from Infected Wheat.

Pseudomonas syringae pv. lapsa is a pathovar of Pseudomonas syringae that can infect wheat. The complete genome of P.

[Efficacy observation of treating diabetic nephropathy by shenshuaining granule combined telmisartan tablet].

Objective: To observe the effect of Shenshuaining Granule (SG) combined telmisartan on serum creatinine (SCr) levels and urinary albumin contents in diabetic nephropathy (DN) patients, and to explore its efficacy.

Methods: Totally 204 DN patients were recruited, and further assigned to 3 groups, i.e.

Chromogenic and fluorescent 'turn-on' chemodosimeter for fluoride based on a F(-)-triggered cascade reaction.

We developed a new chromogenic and fluorescent 'turn-on' chemodosimeter 1 based on a F(-)-triggered cascade reaction. This system displayed significant changes in UV/vis absorption and fluorescence emission intensities selectively for F(-) over other anions in a mixture of CH3CN/H2O(95 : 5, v/v) and in acetonitrile.