A supramolecular organometallic drug complex with HO self-provision intensifying intracellular autocatalysis for chemodynamic therapy.

Chemodynamic therapy (CDT) can efficiently combat tumor cells through a robust catalyst in the presence of HO. However, the insufficient intracellular HO level and inefficiency of catalysts in tumor cells limit the production of enough toxic hydroxyl radicals (˙OH) to achieve satisfactory efficacy for CDT. Herein, a supramolecular organometallic drug complex (SOMDC) with HO self-provision was proposed to intensify the intracellular autocatalysis for enhancing the CDT effect.

Host-guest interaction-based supramolecular prodrug self-assemblies for GSH-consumption augmented chemotherapy.

The over-expressed cellular glutathione (GSH) severely restricts the chemotherapeutic efficacy due to the GSH-induced detoxification of chemical drugs. Herein, how to construct effective drug delivery systems with GSH-consumption property is still a general concern and a major challenge. In this study, the host-guest interactions between water-soluble pillar[6]arene (WP[6]) and chlorambucil-arylboronic acid (Cb-BA) were utilized to construct supramolecular prodrug self-assemblies (SPSAs) with specific stimuli-responsive property.

Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.

Background: Thymus quinquecostatus Celak. has been widely used as a spice and a folk medicine for relieving exterior syndrome and alleviating pain in China.

Purpose: To explore the protective effects and the underlying mechanism against cerebral ischemia-reperfusion injury (CIRI) of the T.

Profile of volatile compounds in 11 brandies by headspace solid-phase microextraction followed by gas chromatography-mass spectrometry.

A headspace solid-phase microextraction (HS-SPME) method coupled with gas chromatography-mass spectrometry (GC-MS) was applied for the qualitative or semiquantitative characterization of brandy volatiles. SPME variables (SPME fiber, extraction temperature and time, and ethanol concentration) were optimized. A total of 144 compounds were from the brandies' volatiles, tentatively identified or identified by comparing mass spectra and retention indices of the standards or from literature.