Exploration of Lipid Metabolism Alterations in Children with Active Tuberculosis Using UHPLC-MS/MS.

Metabolic profiling using nonsputum samples has demonstrated excellent performance in diagnosing infectious diseases. But little is known about the lipid metabolism alternation in children with tuberculosis (TB). Therefore, the study was performed to explore lipid metabolic changes caused by infection and identify specific lipids as diagnostic biomarkers in children with TB using UHPLC-MS/MS.

Clinical characteristics of 1020 childhood-onset systemic lupus erythematosus: data from a health centre in China.

Objectives: Childhood-onset systemic lupus erythematosus (cSLE) is a multisystem autoimmune disease characterised and presents partially differently from adults. A large cSLE cohort study is lacking in China. The present study aimed to determine the clinical characteristics in a large population of patients with cSLE, and compare with adult-onset SLE (aSLE) in an SLE cohort of China.