Publications by authors named "Baixi Li"
Emerging and potential influenza pandemics still are an enormous worldwide public health challenge. The PA endonuclease has been proved to be a promising target for anti-influenza drug design. Here, we report the discovery and optimization of potent Y-shaped PA inhibitors featuring multi-site binding characteristics with l-DOPA as a starting point.
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- Influenza PA inhibitors are crucial for creating new antiviral drugs due to rising pathogenic influenza strains and resistance to current treatments.
- Researchers have developed 1,3-cis--substituted-1,2,3,4-tetrahydroisoquinoline derivatives to enhance their effectiveness by targeting specific regions in the PA endonuclease.
- The lead compound showed strong antiviral properties in lab tests and a mouse model by binding to the PA endonuclease, inhibiting viral replication and demonstrating the potential of these derivatives in combating influenza.
The recent global Omicron epidemics underscore the great need for the development of small molecule therapeutics with appropriate mechanisms. The trimeric spike protein (S) of SARS-CoV-2 plays a pivotal role in mediating viral entry into host cells. We continued our efforts to develop small-molecule SARS-CoV-2 entry inhibitors.
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