Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer.

Background: The long non-coding RNAs (lncRNAs) have been shown as a novel class of transcripts with no protein coding functions. LncRNAs can play diverse roles in cancer cell proliferation, differentiation, metastasis, and apoptosis. However, the exact contributions of lncRNA KDM5B anti-sense RNA 1 (KDM5BAS1) to non-small cell lung cancer (NSCLC) remain poorly understood.

[Retracted] Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer.

Following the publication of this article, an interested reader drew to our attention that Figs. 3B and 4B contained histological data which had previously been published in Figs. 3B and 4B, respectively, of the following article: Wiggins JF, Ruffino L, Kelnar K, Omotola M, Patrawala L, Brown D and Bader AG: Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34.

Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer.

MicroRNAs (miRNAs) can function as tumor suppressors and may provide an efficient strategy for the eradication of cancer. Specific miRNAs can be reintroduced into tumor cells to complement loss of tumor suppression activities. The aim of the present study was to develop miRNA delivery formulation using synthesized miR-451.