Therapeutic effect and mechanism of danshensu on coronary heart disease using liquid chromatography combined with mass spectrometry metabolomics.

Metabolomics can discover the biomarkers and metabolic pathways, provides the possibility for insights into the pharmacological action and mechanism of natural products. The therapeutic effect and mechanism of danshensu (DSS) on total metabolic pathways has not been well investigated. The aim of this study was to explore the disturbed endogenous biomarkers and metabolic pathways reflecting the pharmacological activity of DSS, and mechanism of action of DSS using comprehensive metabolome analysis based on high-throughput metabolomics technology combined with ultra-high performance liquid chromatography (UPLC) coupled with quadrupole tandem time-of-flight mass spectrometry (Q-TOF-MS) and pattern recognition method.

Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups.

This study aimed to evaluate the role of off-pump coronary artery bypass (CAB) surgery on the decrease of postoperative inflammatory responses in patients. We systematically searched databases of PubMed and Embase to select the related studies. Interleukin (IL) 6, 8, and 10 were used as outcomes and pooled analysis was performed using R 3.

Parathyroid hormone and risk of heart failure in the general population: A meta-analysis of prospective studies.

Inconsistent findings have been reported on the association between the parathyroid hormone (PTH) level and risk of heart failure. We aimed to systematically evaluate the association between circulating level of PTH and risk of heart failure in the general population by conducting a meta-analysis. We made a comprehensive literature search in PubMed, Embase, VIP, CNKI, and Wanfang databases published until January 2016.

Obstructive sleep apnea syndrome is a risk factor of hypertension.

Introduction: Some studies investigated the association between obstructive sleep apnea syndrome (OSAS) and hypertension risk. However, the results remained inconclusive. Thus, we performed a meta-analysis to clarify the association of OSAS and hypertension risk.

Elevated levels of serum S100B is associated with the presence and outcome of haemorrhagic shock.

Background: Serum S100B was suggested to be elevated after brain damage in previous studies. Nowadays, increasing evidence has revealed S100B was also elevated in other tissue traumas outside the brain such as bone fracture and acute coronary syndrome. The aim of this study is to investigate whether the level of serum S100B is associated with haemorrhagic shock (HS), as well as multiple organ failure (MOF) and mortality in patients with HS.

Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer.

Aim: Genetic and environmental factors may play roles in the pathogenesis of esophageal cancer and susceptibility may be modified by functional polymorphisms in folate metabolic genes, such as methylenetetrahydrofolate reductase (MTHFR). We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer.

Methods: A matched hospital-based case-control study with 155 esophageal cancer and 310 non-cancer controls was conducted in Southern of China with gene-environment interactions evaluated between the MTHFR C667T polymorphism and drinking and smoking, as well as folate intake.

[Effect of acupuncture on the expression of Bcl-xl and BDNF of retina in rabbits with chronic intraocular hypertension].

Objective: To explore the protection effects of acupuncture on glaucomatous optic nerve damage and its mechanism.

Methods: Experimental glaucoma model was induced by intracameral injection of compound Carbomer solution in rabbits. After 28 days, ocular tension returned to normal by filtration surgery.

Diagnosis and surgical treatment of adult aortico-right ventricular tunnel.

Aortico-right ventricular tunnel (ARVT) was successfully corrected in a 32-year-old patient. The diagnosis was preoperatively suspected on the basis of Doppler echocardiography and it was confirmed by a three-dimensional computed tomographic scan. The ARVT originated independently above the right coronary sinus.