[Blood group and human diseases (review of literature).].

AB0 blood group antigens were discovered over a century ago; however, it is still important to study their role in development of various pathological conditions. Today it is known that antigenic determinants of this blood group are present not only on erythrocyte membrane but also on other cells and tissues: platelets, gastrointestinal epithelium and salivary glands, respiratory system cells. In the last decade, a large number of studies have appeared to reveal the relationship between a specific disease and blood group type, meta-analyses have been published.

[Saliva diagnostic in the research about human immune adaptation to study stress and to differrent water drinking behavior.].

85 healthy young people were participates of a randomized placebo controlled cross-over fashion. This study tested associations between different water drinking behavior, the condition of oral immune protection and stress factors over 3 months. We examined saliva IL-1, IL-4, IL-6, TNF-α, γ-IFN, α-amylase and compared them with stress-associated psychophysiological data.

[Modeling role of pyruvate in the processes of protein-protein interaction].

Using the ABO antibody-antigen model the influence of natural metabolite pyruvate on the antibody interaction with of erythrocyte antigens, defining their group specificity has been investigated. Before agglutination reaction erythrocytes of A(II)-AB(IV) blood groups, monoclonal anti-A and anti-B antibodies were incubated with sodium pyruvate. Visualization of agglutinates was performed by means of flow cytometry and laser scanning confocal microscopy.

[The role of small molecules in regulation of activity of cytoplasmatic dehydrogenases].

The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), alpha-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH. The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide.

[Biological value of Silybum marianum oil].

We are introduced the dates on an elemental compositional and physiochemical parameters of oil Silybum Marianum. In this assay we compare oil Silybum Varianum with the most widespread food oils. Presented perspectives of usage oil Silymum Marianym as the food and medical oil.

[The role of hyperlactatedehydrogenasemia in induction of metabolic disorders in the body].

The effect of intravenous administration of lactate dehydrogenase (5000 E/kg) on some metabolic parameters was investigated. The hyperenzymemia was accompanied by changes of metabolite content (glutamate, 2-oxoglutarate, lactate, dihydroxyacetone phosphate) and enzyme activities (aldolase, lactate dehydrogenase, transaminase) in heart, liver and skeletal muscles. Intravenously administered tritiated lactate dehydrogenase was preferentially found in skeletal muscles, liver, kidneys and some other organs.

[Effect of biologically active components of natursil on the course of reparative processes in the gastrointestinal mucosa in experiments and in patients with stomach and duodenal ulcers].

The outcomes, obtained in experiment, testify about high reparative ability of a natursilum. Natursilum has growth efficiency of conventional treatment of an ulcer of a stomach and duodenal intestine patients both on end results, and on terms of an adhesion increases. Is rotined, that natursilum has more expressed antiulcerous effect, than oil of hippopheae.

[The relationship of population morbidity to specific industrial wastes].

The present-day ecological crisis progressively deteriorates the population's health and demographic indices. Since 1990 primary morbidity has shown a 50.2% increase in the town of Samara.