Publications by authors named "Bairu Lai"
Article Synopsis
- - The study aims to investigate the genetic and physical traits of carriers of the c.316-146T > G mutation in China.
- - Researchers used various methods like PCR and DNA sequencing to analyze blood parameters and hemoglobin patterns, finding specific characteristics in the carriers, such as low MCV and MCH values.
- - Results showed the carriers exhibited symptoms similar to those of common β heterozygous mutations, indicating the need for further genetic testing if initial results don't correlate with the hematological phenotype.
Objective: To analyze the hematological phenotype and genotype of : c.96-2A > G carriers.
Methods: The blood routine parameters and hemoglobin electrophoresis of rare cases were analyzed and identified by PCR combined with reverse dot blot (RBD-PCR), GAP-PCR and DNA sequencing.
This study aimed to analyze the clinical phenotype of the : c.95G>A mutation in the Chinese population and to provide guidance for clinical diagnosis and genetic counseling. Peripheral blood samples were collected from 16 patients, including 6 newborns, 2 children, and 8 adults.
View Article and Find Full Text PDF[Analysis of five Chinese individuals with rare thalassemia mutation HBB: c.93-21G＞A].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2024
Article Synopsis
- The study aimed to investigate the blood characteristics and genetic makeup of five Chinese individuals carrying a rare thalassemia mutation (HBB: c.93-21G＞A).
- It involved a retrospective analysis using blood tests and advanced genetic techniques to identify hematological profiles and mutations in the subjects.
- Findings indicated that most individuals showed mild β-thalassemia features, with certain genetic variations present among the cases studied.
Objective: To investigate the clinical characteristics and risk factors of patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases.
Methods: A retrospective analysis of general clinical data was conducted on patients with SARS-CoV-2 omicron infection complicated with hypertension, coronary heart disease, and heart failure admitted to one hospital in Guangdong Province from December 1, 2022, to February 28, 2023. Clinical symptoms, laboratory tests, imaging examinations, treatment, and clinical outcomes were collected.