Publications by authors named "Baiqiang Xue"
Background: Mosaic chromosomal alterations are implicated in neuropsychiatric disorders, but the contribution to schizophrenia (SCZ) risk for somatic copy number variations (sCNVs) emerging in early developmental stages has not been fully established.
Methods: We analyzed blood-derived genotype arrays from 9715 patients with SCZ and 28,822 control participants of Chinese descent using a computational tool (MoChA) based on long-range chromosomal information to detect mosaic chromosomal alterations. We focused on probable early developmental sCNVs through stringent filtering.
Article Synopsis
- Abnormal sleep patterns are significantly linked to various brain disorders, with a need for deeper understanding of their genetic similarities and causal connections.
- Using advanced genetic analysis methods on extensive datasets, researchers identified numerous genetic correlations and causal relationships between six sleep traits and 24 brain disorders, particularly psychiatric conditions.
- The findings highlight specific genes and pathways involved, illustrating how sleep traits, especially insomnia, can influence conditions like major depression, while also revealing a complex interplay among different sleep-related factors and brain health.