Estimated summer abundance and krill consumption of fin whales throughout the Scotia Sea during the 2018/2019 summer season.

Among large cetaceans in the Southern Hemisphere, fin whales were the most heavily exploited in terms of numbers taken during the period of intense industrial whaling. Recent studies suggest that, whilst some humpback whale populations in the Southern Hemisphere appears to have almost completely recovered to their estimated pre-whaling abundance, much less is known about the status of Southern Hemisphere fin whales. Circumpolar estimates in the 1990s suggest an abundance of about 5500 animals south of 60° S, while the IDCR/SOWER-2000 survey for the Scotia Sea and Antarctic Peninsula areas estimated 4670 fin whales within this region in the year 2000.

Predicting suitable coastal habitat for sei whales, southern right whales and dolphins around the Falkland Islands.

Species distribution models (SDMs) are valuable tools for describing the occurrence of species and predicting suitable habitats. This study used generalized additive models (GAMs) and MaxEnt models to predict the relative densities of four cetacean species (sei whale Balaeanoptera borealis, southern right whale Eubalaena australis, Peale's dolphin Lagenorhynchus australis, and Commerson's dolphin Cephalorhynchus commersonii) in neritic waters (≤100 m depth) around the Falkland Islands, using boat survey data collected over three seasons (2017-2019). The model predictor variables (PVs) included remotely sensed environmental variables (sea surface temperature, SST, and chlorophyll-a concentration) and static geographical variables (e.

A new family of mathematical models describing the human growth curve-Erratum: direct calculation of peak height velocity, age at take-off and associated quantities.

A new family of mathematical functions to fit longitudinal growth data was described in 1978. The ability of researchers to directly use parameters as estimates of age at peak height velocity resulted in them overlooking the possibility of directly calculating these quantities after model estimation. This erratum has corrected three mistakes in the original manuscript in the direct calculation of peak height velocity and age at take-off and has implemented the solutions in a STATA program which directly calculates the estimates, standard errors and confidence intervals for age, height and velocity at peak height velocity.

Superfast nonlinear diffusion: capillary transport in particulate porous media.

The migration of liquids in porous media, such as sand, has been commonly considered at high saturation levels with liquid pathways at pore dimensions. In this Letter, we reveal a low saturation regime observed in our experiments with droplets of extremely low volatility liquids deposited on sand. In this regime, the liquid is mostly found within the grain surface roughness and in the capillary bridges formed at the contacts between the grains.

Evaluation of a revised curriculum: a four-year qualitative study of student perceptions.

Following curricular revisions at the Virginia Commonwealth University School of Dentistry, this longitudinal study was designed to determine students' perceptions of their educational experience in the revised curriculum. A SWOT (Strengths, Weaknesses, Opportunities, and Threats) open-ended response questionnaire was administered to students in the class of 2011 (N=89) in January of each academic year, 2008 through 2011, followed by focus groups three months prior to graduation. The overall response rate for the questionnaire was 69 percent, and a total of fourteen students participated in four focus groups.

Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients.

Introduction: Oxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress.

The association between cysteine, bone turnover, and low bone mass.

Background: With the identification of hyperhomocysteinemia as a risk factor for developing osteoporosis, the contribution of thiols metabolically linked with homocysteine (tHcy) may be of importance. Cysteine (Cys) is formed from tHcy and is involved in bone metabolism via incorporation into collagen and cysteine protease enzymes.

Methods: We investigated the association of plasma Cys and related thiols, the bone turnover markers C-telopeptide (CTX) and procollagen type 1 N propeptide (P1NP) and folate and vitamin B(6) with calcaneal bone mineral density (BMD) in 328 postmenopausal British women grouped according to their BMD measurement.

Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations.

Background: After major burns, patients can develop nutritional deficiencies including trace element (TE) deficiencies. Various complications, such as infections and delayed wound healing, influence the clinical course of such patients.

Objectives: We aimed to investigate the effects of large, intravenous doses of TE supplements on circulating and cutaneous TE tissue concentrations, on antioxidant status, and on clinical outcome after major burns.

Effect of selenium supplementation on biochemical markers and outcome in critically ill patients.

Background & Aims: This study aimed to assess the effect of high dose selenium (Se) supplementation on Se status in blood, oxidative stress, thyroid function and possible effects on requirement for renal replacement therapy (RRT) in severely septic patients admitted to the intensive care unit (ICU).

Methods: This prospective single-centre study was carried out in 40 septic ICU patients who were randomized to high dose Se (Se+ group, N=18 (474, 316, 158 microg/day), each for 3 consecutive days followed by a standard dose of 31.6 microg/day of Se given as sodium selenite whereas the control group (Se-, N=22) received only the standard dose of Se.

The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women.

We studied the association between plasma total homocysteine (tHcy), its determinants folate, vitamin B(12), vitamin B(6) and MTHFR genotype, and bone mineral density (BMD) in 328 postmenopausal British women. When the subjects were assigned to one of 3 groups (control, osteopenic or osteoporotic) according to their BMD at the os calcis, those in the osteoporotic group had, compared with the controls, a significantly lower serum folate concentration, a significantly higher % of current smokers and a significantly higher incidence of recent fracture. In the population as a whole, we found significant associations of BMD with tHcy (r=-0.

Chemoattraction of inflammatory cells by various intraocular lens materials.

Purpose: To compare the chemotactic activity induced by polymethyl methacrylate (PMMA), acrylic, and silicone intraocular lens (IOL) materials, regardless of the surgical and host factors.

Methods: The chemotactic effect of five different IOLs was studied using a modified multi-well Boyden chamber. Two different non-coated PMMA IOLs, a heparin-coated PMMA IOL, an acrylic IOL, and a silicone IOL were assessed.

Markers of oxidative damage, antioxidant status and clinical outcome in critically ill patients.

Background: Oxidative stress is a consequence of critical illness, and may have an impact on survival. We studied markers of oxidative damage and antioxidant (AO) protection and compared them with clinical scores and outcome.

Methods: Blood sampling and clinical scoring was carried out on 60 consecutively admitted intensive therapy unit (ITU) patients within 24 h of admission and then every three days of ITU stay.

Face-offs in reproductive immunology: the Montreal forum meeting report.

The combined 12th International Congress of Immunology (ICI) and the 4th Annual Conference of the Federation of Clinical Immunological Societies (FOCIS) was held in Montreal, Canada July 18-23, 2004 and attracted over 6000 immunologists and almost 4000 abstracts. The host society, the Canadian Society for Immunology (CSI) spent many years in preparation for this large meeting and encouraged its members to propose topics for symposia and mini-symposia and to sponsor satellite meetings. With sponsorship of CSI; the Canadian Institutes of Health Research; the University of Guelph, Guelph, ON; Queen's University, Kingston, ON; McGill University, Montreal, QU, Canada; and the American Society for Reproductive Immunology, a focused, highly successful, one day satellite meeting on human uterine immunology was held.

Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients.

Background: Acute renal failure is a serious complication in critically ill patients and frequently requires renal replacement therapy, which alters trace element and vitamin metabolism.

Objective: The objective was to study trace element balances during continuous renal replacement therapy (CRRT) in intensive care patients.

Design: In a prospective randomized crossover trial, patients with acute renal failure received CRRT with either sodium bicarbonate (Bic) or sodium lactate (Lac) as a buffering agent over 2 consecutive 24-h periods.

Evaluation of a clinical screening instrument to identify states of thiamine deficiency in inpatients with severe alcohol dependence syndrome.

Aims: To develop a Thiamine Deficiency Questionnaire (TDQ), and to assess its reliability in the identification of Thiamine deficiency, in patients with severe alcohol dependence.

Methods: 58 severely alcohol dependent patients underwent socio-demographic, medical, psychiatric, and alcohol use assessment, including administration of the Thiamine Deficiency Questionnaire (TDQ). The Red Blood Cell Thiamine Pyrophosphate concentration provided the 'gold standard' to test the validity of the instrument.

Chemotactic and chemokinetic properties of topical ophthalmic preparations.

Purpose: Chronic ocular inflammation can be due to a disease process or to iatrogenic factors that attract inflammatory cells to the anterior chamber. This study was conducted to investigate the effect of commonly used ophthalmic preparations on leukocyte migration.

Methods: A modified multi-well Boyden chamber was used to study the chemotactic and chemokinetic effects of 33 commercial ophthalmic preparations.

Use of antioxidants in surgery: a measure to reduce postoperative complications.

Purpose Of Review: This review highlights recent research into the causes and prevention of free radical (particularly reactive oxygen species)-induced surgical complications. Experimental and clinical studies have contributed new understanding of the sources of free radical attack, modalities to counter these and newer approaches developed with the aid of molecular biology.

Recent Findings: Most work has centred on cardiac bypass surgery, other surgery involving ischaemia and reperfusion, and transplant surgery.

The management of gastric outlet obstruction secondary to inoperable cancer.

Background: Historically, the distressing symptoms of malignant gastric outlet obstruction have been best managed by open gastrojejunostomy. We provide an assessment of an alternative laparoscopic technique.

Methods: We reviewed eight patients undergoing laparoscopic gastrojejunostomy.

Spinal cord compression--a personal and palliative care perspective.

Malignant spinal cord compression is recognized as an oncological emergency. In spite of this, treatment in the U.K.

Lack of effectiveness of short-term intravenous micronutrient nutrition in restoring plasma antioxidant status after surgery.

Background And Aims: Many patients recovering from surgery may be in a state of negative antioxidant balance. For those whose postoperative nutritional requirements are provided intravenously, this may not be adequate for antioxidant repletion. This study was undertaken to assess the total antioxidant status of these patients peri-operatively and prior to beginning intravenous nutrition (IVN), and to determine the adequacy of IVN, including daily micronutrients, in maintaining or restoring antioxidant status in the post-operative period.

Clinical-practice recommendations for the management of bowel obstruction in patients with end-stage cancer.

The paper highlights a series of questions that doctors need to consider when faced with end-stage cancer patients with bowel obstruction: Is the patient fit for surgery? Is there a place for stenting? Is it necessary to use a venting nasogastric tube (NGT) in inoperable patients? What drugs are indicated for symptom control, what is the proper route for their administration and which can be administered in association? When should a venting gastrostomy be considered? What is the role of total parenteral nutrition (TPN) and parenteral hydration (PH)? A working group was established to review issues relating to bowel obstruction in end-stage cancer and to make recommendations for management. A steering group was established by the (multidisciplinary) Board of Directors of the European Association for Palliative Care (EAPC) to select members of the expert panel, who were required to have specific clinical and research interests relating to the topic and to have published significant papers on advanced cancer patients in the last 5 years, or to have particular clinical expertise that is recognised internationally. The final constitution of this group was approved by the Board of the EAPC.

Interferon activation and innate immunity.

The interferons are a family of cytokine mediators critically involved in alerting the cellular immune system to viral infection of host cells. Interferons not only exhibit important antiviral effects but also exert a key influence on the quality of the cellular immune responses and amplify antigen presentation to specific T cells. Type I interferon (IFN-alpha and IFN-beta) is secreted by virus-infected cells while type II, immune or gamma interferon (IFN-gamma) is mainly secreted by T cells, natural killer (NK) cells and macrophages.

Homocysteine and thiol metabolites in vitamin B12 deficiency.

Homocysteine metabolism is increasingly implicated in a diverse group of clinical disorders, including atheromatous vascular disease. We studied the disposition of homocysteine via the trans-sulphuration pathway, plasma glutathione peroxidase (GPx) activity and plasma levels of the sulphated hormone dehydro-epiandrosterone sulphate (DHEAS) in six vitamin B(12)-deficient human subjects before and after 2 weeks of vitamin B(12) repletion, both in the fasting state and following an oral methionine load (0.1 g/kg body weight).

Symptom control in advanced gastrointestinal cancer.

Patients with advanced gastrointestinal cancer develop many symptoms as the disease progresses. However, the common problems of pain, nausea and vomiting, anorexia, constipation and intestinal obstruction can all be relieved by appropriate pharmacological treatment.