Publications by authors named "Baiming Huang"

Article Synopsis
  • The study analyzed over 1,000 blood samples from patients infected with the Omicron variant of SARS-CoV-2 to understand the host's immune response using various advanced techniques, known as multi-omics.
  • Researchers found that Omicron infections led to increased antiviral activity in platelets and changes in how these cells interacted with other immune cells, highlighting a unique immune response.
  • The study also identified a decrease in B cell activity and antibody production in patients who tested positive again for the virus, while a machine learning model was developed to predict the likelihood of re-positivity in these patients.
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Platelets, the chief effector of hemostasis, are small anucleate blood cells generated from megakaryocytes (MKs), and the defects in platelet production or function lead to a variety of bleeding complications. Emerging evidence indicates that MKs and platelets are much more diverse than previously appreciated and involved in many physiological and pathological processes besides hemostasis, such as innate and adaptive immune responses, angiogenesis, and tumor metastasis, while the ontogenic variations in MK and platelet function have also become a focus in the field. However, whether MKs and platelets fulfill these distinct functions by utilizing distinct subpopulations remains poorly understood.

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Despite our growing understanding of embryonic immune development, rare early megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA sequencing of human MKs from embryonic yolk sac (YS) and fetal liver (FL) to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis. In the YS and FL, we found heterogeneous MK subpopulations with distinct developmental routes and patterns of gene expression that could reflect early functional specialization.

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