Publications by authors named "Baily Wang"
Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors.
Am J Physiol Endocrinol Metab
March 2024
Article Synopsis
- Oocyte maturation in mammals relies on a supportive relationship with cumulus cells, which are influenced by oocyte-secreted factors (OSFs) like cumulin and BMP15.
- These OSFs change both the metabolic activities and protein profiles of oocytes and cumulus cells, promoting anabolic processes and altering mitochondrial functions.
- Overall, the findings suggest that OSFs help coordinate the metabolic needs of cumulus cells to support oocyte maturation while minimizing the metabolic activities of the oocyte itself in preparation for embryonic development.