HMGA1 influence on iron-induced cell death in Tfh cells of SLE patients.

The autoimmune disorder known as Systemic Lupus Erythematosus (SLE) exhibits intricate features with abnormal immune responses leading to tissue injury. The generation of antibodies and the disruption of immune regulation heavily depend on the pivotal function of T follicular helper (Tfh) cells. Iron dysregulation is significant in autoimmune diseases, impacting immune cell function and disease progression.

IFN-γ promotes the development of systemic lupus erythematosus through the IFNGR1/2-PSTAT1-TBX21 signaling axis.

Background: Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in cartilage and the lining of blood vessels. Emerging evidence implicates IFN-γ as a major effector molecule in SLE during both active and stable stages. Here, we investigated the effects of IFN-γ on cytokines that play an autoimmune disease-promoting role and Th1-versus-Th2 and B cell dualism in SLE patients and mouse models of SLE.

Event-Based Robust Optimal Consensus Control for Nonlinear Multiagent System With Local Adaptive Dynamic Programming.

This article investigates the robust optimal consensus for nonlinear multiagent systems (MASs) through the local adaptive dynamic programming (ADP) approach and the event-triggered control method. Due to the nonlinearities in dynamics, the first part defines a novel measurement error to construct a distributed integral sliding-mode controller, and the consensus errors can approximately converge to the origin in a fixed time. Then, a modified cost function with augmented control is proposed to deal with the unmatched disturbances for the event-based optimal consensus controller.

Game of Drones: Multi-UAV Pursuit-Evasion Game With Online Motion Planning by Deep Reinforcement Learning.

As one of the tiniest flying objects, unmanned aerial vehicles (UAVs) are often expanded as the "swarm" to execute missions. In this article, we investigate the multiquadcopter and target pursuit-evasion game in the obstacles environment. For high-quality simulation of the urban environment, we propose the pursuit-evasion scenario (PES) framework to create the environment with a physics engine, which enables quadcopter agents to take actions and interact with the environment.

Distributed Pursuit of an Evader With Collision and Obstacle Avoidance.

The distributed, real-time algorithms for multiple pursuers cooperating to capture an evader are developed in an obstacle-free and an obstacle-cluttered environment, respectively. The developed algorithm is based on the idea of planning the control action within its safe, collision-free region for each robot. We initially present a greedy capturing strategy for an obstacle-free environment based on the Buffered Voronoi Cell (BVC).

Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review).

Numerous recent studies reported that brain-derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apoptosis of lymphocytes. Peripheral lymphocytes express both BDNF and its receptors.

The effectiveness of physical exercise type and length to prevent falls in nursing homes: A systematic review and meta-analysis.

Objective: The aim of this systematic review and meta-analysis was to determine the effect of physical exercise on fall prevention and the characteristics required for effective exercise.

Design: Systematic review and meta-analysis of randomised controlled trials.

Method: Six databases (PubMed, Cochrane Library, Web of Science, Excerpta Medica Database, SinoMed and China National Knowledge Infrastructure) were searched to find the relevant randomised controlled trials published before January 2021.

Altered peripheral helper T cells in peripheral blood and muscle tissue of the patients with dermatomyositis.

Peripheral helper T (Tph) cells, phenotypically PD-1hiCXCR5-CD4+, are a recently identified Th cell subset that relates to several autoimmune diseases. Contrary to PD-1hiCXCR5+CD4+ follicular helper T (Tfh) cells, Tph cells are not located in lymphoid organs but accumulate in inflamed tissues. This study investigated Tph cells to determine their involvement in dermatomyositis (DM).

Increased Levels of VCAM-1 in Sera and VLA-4 Expression on Neutrophils in Dermatomyositis with Interstitial Lung Disease.

Vascular cell adhesion molecule-1 (VCAM-1) and its ligand very late antigen (VLA-4) play important roles in many autoimmune diseases. Our study aimed to investigate the serum level of VCAM-1 and VLA-4 expression on peripheral blood neutrophil surface in patients with dermatomyositis (DM), especially focusing on patients with interstitial lung disease (ILD). Blood specimens of 42 patients with DM and 42 healthy controls matched for age and gender were recruited.

Finite-Time Dynamic Allocation and Control in Multiagent Coordination for Target Tracking.

A new finite-time dynamic allocation and control scheme is developed in this article for multiple agents tracking a moving target. Based on a competitive manner, the dynamic allocation is achieved by k-winners-take-all (k-WTA), which can be realized by a novel finite-time dual neural network with the adaptive-gain activation function. Then, a finite-time disturbance compensation-based control law is proposed for agents to conduct capturing task or return to the specified point in vigilance.

Peripheral blood brain-derived neurotrophic factor level and tyrosine kinase B expression on T lymphocytes in systemic lupus erythematosus: Implications for systemic involvement.

Objective: Brain-derived neurotrophic factor (BDNF) has been reported to be involved in the pathogenesis of autoimmune diseases and tyrosine kinase B (TrkB) is the specific receptor for BDNF. Our aim in this study was to investigate serum BDNF level and TrkB expression on peripheral blood T cell surface in patients with systemic lupus erythematosus (SLE) and explore potential relationship between serum BDNF and SLE.

Methods: Samples from fifty SLE patients and thirty healthy controls were evaluated.

Integrated Fault Estimation and Fault-Tolerant Tracking Control for Lipschitz Nonlinear Multiagent Systems.

An integrated fault estimation (FE) and fault-tolerant tracking control (FTTC) strategy is developed for Lipschitz nonlinear multiagent systems subject to actuator faults, external disturbance, and uncertainties. First, for each agent, a corresponding unknown input observer with reduced/full order is constructed to obtain the FE. Then, a state/output feedback FTTC strategy is proposed based on the integral sliding-mode technique and adaptive super-twisting algorithm.

Fixed-Time Leader-Follower Output Feedback Consensus for Second-Order Multiagent Systems.

This paper addresses the fixed-time leader-follower consensus problem for second-order multiagent systems without velocity measurement. A new continuous fixed-time distributed observer-based consensus protocol is developed to achieve consensus in a bounded finite time fully independent of initial condition. A rigorous stability proof of the multiagent systems by output feedback control is presented based on the bi-limit homogeneity and the Lyapunov technique.

Neural network disturbance observer-based distributed finite-time formation tracking control for multiple unmanned helicopters.

The distributed finite-time formation tracking control problem for multiple unmanned helicopters is investigated in this paper. The control object is to maintain the positions of follower helicopters in formation with external interferences. The helicopter model is divided into a second order outer-loop subsystem and a second order inner-loop subsystem based on multiple-time scale features.

Control-oriented modeling and adaptive backstepping control for a nonminimum phase hypersonic vehicle.

In this paper, the nonminimum phase problem of a flexible hypersonic vehicle is investigated. The main challenge of nonminimum phase is the prevention of dynamic inversion methods to nonlinear control design. To solve this problem, we make research on the relationship between nonminimum phase and backstepping control, finding that a stable nonlinear controller can be obtained by changing the control loop on the basis of backstepping control.

Continuous high order sliding mode controller design for a flexible air-breathing hypersonic vehicle.

This paper investigates the problem of tracking control with uncertainties for a flexible air-breathing hypersonic vehicle (FAHV). In order to overcome the analytical intractability of this model, an Input-Output linearization model is constructed for the purpose of feedback control design. Then, the continuous finite time convergence high order sliding mode controller is designed for the Input-Output linearization model without uncertainties.