Metal-organic framework bearing new viologen ligand for ammonia and CrO sensing.

Three anionic metal-organic frameworks (MOFs) {[Zn(BTEC)(HO)(4-BCBPY)]·(HO)} (1-3) (BTEC = 1,2,4,5-benzenetetracarboxylic acid anion, 4-BCBPY = 1,1'-bis(4-cyanobenzyl)-4,4'-bipyridinium dication) were synthesized in the reaction of 1,2,4,5-benzenetetracarboxylic acid with different metal salts such as ZnNO, ZnCl, and ZnSO, under solvothermal conditions in the presence of 1,1'-bis(4-cyanobenzyl)-4,4'-bipyridinium chloride. Single crystal X-ray diffraction analysis shows that compounds 1, 2 and 3 have MOF structures based on binuclear metal building units, which are connected by two protonated BTEC ligands and three zinc ions, and the viologen cation 4-BCBPY is located in the channel to achieve charge balance. Compounds 1, 2 and 3 have good photosensitivity, respond to sunlight, UV light and blue ray, and turn blue.

HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.

The cellular BRCA1 protein level is essential for its tumor suppression activity and is tightly regulated through multiple mechanisms including ubiquitn-proteasome system. E3 ligases are involved to promote BRCA1 for ubiquitination and degradation. Here, we identified HUWE1/Mule/ARF-BP1 as a novel BRCA1-interacting protein involved in the control of BRCA1 protein level.

HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.

The cellular BRCA1 protein level is essential for its tumor suppression activity and is tightly regulated through multiple mechanisms including ubiquitn-proteasome system. E3 ligases are involved to promote BRCA1 for ubiquitination and degradation. Here, we identified HUWE1/Mule/ARF-BP1 as a novel BRCA1-interacting protein involved in the control of BRCA1 protein level.