Publications by authors named "Bailey Spiegelberg"
Article Synopsis
- Primary human trophoblast stem cells (TSCs) and those derived from human pluripotent stem cells (hPSCs) can be modeled in the lab, but how hPSCs differentiate into TSCs is not well understood.
- This study shows that a specific primed pluripotent state can produce TSCs by activating certain pathways (like EGF and WNT) and inhibiting others (like TGFβ and ROCK), all without adding BMP4, referred to as the TS condition.
- The researchers found that the TSCs generated under TS conditions can proliferate extensively and closely resemble first-trimester placental cells, suggesting that primed hPSCs can differentiate into TSCs through various
Recombinant inbred lines (RILs) are an important resource for mapping genes controlling complex traits in many species. While RIL populations have been developed for maize, a maize RIL population with multiple teosinte inbred lines as parents has been lacking. Here, we report a teosinte nested association mapping (TeoNAM) population, derived from crossing five teosinte inbreds to the maize inbred line W22.
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