Publications by authors named "Baijing Ding"
Article Synopsis
- Anti-tumor necrosis factor (TNF) monoclonal antibodies, particularly infliximab (IFX) and adalimumab (ADA), are primary treatments for active Crohn's disease, but the role of therapeutic drug monitoring (TDM) in assessing treatment effectiveness is still debated.
- * The study aimed to examine the relationship between serum anti-TNF levels and early endoscopic response in Crohn's disease using a new TDM-based prediction model.
- * Results indicated that higher serum levels of IFX and ADA are linked to better endoscopic responses, and a novel nomogram considering these drug levels and other laboratory markers effectively predicts treatment outcomes.
Background: Histological healing is closely associated with improved long-term clinical outcomes and lowered relapses in patients with ulcerative colitis (UC). Here, we developed a novel diagnostic criterion for assessing histological healing in UC patients.
Methods: We conducted a retrospective cohort study in UC patients, whose treatment was iteratively optimized to achieve mucosal healing at Shanghai Tenth People's Hospital of Tongji University from January 2017 to May 2022.
Article Synopsis
- Glioblastoma multiforme is a highly aggressive brain tumor with treatment challenges due to the blood-brain barrier making drug delivery difficult.
- Researchers developed a new drug delivery system called Ang-cubs-(GNA + PLHSpT) that combines hydrophobic and hydrophilic drugs using specially engineered cubosomes which can effectively penetrate the blood-brain barrier.
- Tests show that this dual-targeting system not only targets brain tumor cells more efficiently but also enhances anti-tumor effects and improves survival rates in vivo compared to traditional treatments.
Clinical significance of expression level of ZNF471 in gastric cancer.
Int J Clin Exp Pathol
August 2023
Background: As a tumor suppressor gene, zinc finger protein 471 (ZNF471) has an essential role in tumor occurrence and development. Due to promoter hypermethylation, it can be underexpressed or silenced in gastric cancer (GC) cell lines. In this study, we investigated relationships between clinical characteristics and ZNF471 expression levels in tissues of patients with GC.
View Article and Find Full Text PDF[Helicobacter pylori promotes gastric cancer metastasis via up-regulating the expression of Bmi-1].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
June 2023
Objective To clarify whether Helicobacter pylori (H. pylori) can promote metastasis of gastric cancer cells via the high-expression of induced B cell specific Moloney murine leukemia virus integration site 1 (Bmi-1). Methods The gastric cancer tissue specimens from 82 patients were collected for this study.
View Article and Find Full Text PDFThe aim of present study was to develop folic acid (FA)-modified nonionic surfactant vesicles (NISVs, niosomes) as carrier systems for targeted delivery of gambogenic acid (GNA). The FA-GNA-NISVs exhibited a mean particle size of 180.77 ± 2.
View Article and Find Full Text PDFIn this study, a novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG-PLA) and poly(ethylene glycol)-poly(ɛ-caprolactone) (mPEG-PCL), used as a novel nanocarrier to encapsulate gambogenic acid (GNA). GNA-loaded mixed polymeric micelles (GNA-MMs) was prepared by cosolvent evaporation method. The mean average size of GNA-MMs was (83.
View Article and Find Full Text PDFBackground/aims: There are many similarities and overlaps in clinical, radiological, endoscopic, and histological features among intestinal tuberculosis (ITB), Crohn's disease (CD), and primary intestinal lymphoma (PIL), and the differential diagnosis of ITB can be very challenging for clinicians.
Patients And Methods: The clinical, radiologic, endoscopic, and pathological data of 213 patients were analyzed retrospectively. According to the diagnostic criteria and exclusive criteria of ITB, CD, and PIL, 83 patients were recruited and divided into three groups, including 30 cases in the ITB group, 38 cases in the CD group, and 15 cases in the PIL group, and the medical data and statistical analysis were recorded.