Publications by authors named "Baihe Zhan"
Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.
Purpose: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.
Streptococcus pneumoniae (S. pneumoniae) is a major Gram-positive opportunistic pathogen that causes pneumonia, bacteremia, and other fatal infections. This bacterium is responsible for more deaths than any other single pathogen in the world.
View Article and Find Full Text PDFEthnopharmacological Relevance: Genkwa flos (yuanhua in Chinese), the dried flower buds of the plant Daphne genkwa Siebold & Zucc., as a traditional herb widely used for the treatment of inflammation-related symptoms and diseases, with the efficacies of diuretic, phlegm-resolving and cough suppressant.
Aim Of The Study: Traditional Chinese Medicine (TCM) is presumed to be of immense potential against pathogens infection.
Article Synopsis
- The mcr-1 gene is causing colistin resistance in bacteria, reducing treatment options for severe infections.
- Researchers found that pogostone can restore colistin's effectiveness against drug-resistant bacteria by preventing MCR-1 from effectively binding to its targets.
- In mouse studies, combining pogostone with colistin significantly increased survival rates and decreased bacterial loads in infected organs compared to using either drug alone.