Expert consensus on the clinical application of ormutivimab injection for use against the rabies virus.

Background: There are no local or international guidelines or consensus on the use of mAbs against the rabies virus.

Research Design And Methods: An expert group in the field of rabies prevention and control formulated the consensus presented in this paper.

Results: Class III exposed persons to rabies for the first time; Identify type II exposed persons with immune deficiency; those who are first exposed to Class II and re-exposed to Class III within 7 days.

Identification of CD44 as a Cell-Surface Marker for Kit Negative Interstitial Cells of Cajal in Adult Mouse Colon.

Loss of Kit protein expression is proven to influence the plasticity of interstitial cells of Cajal (ICCs) and may contribute to gastrointestinal (GI) dysfunctions. The role and fate of Kit negative ICCs are unclear, and cell-specific markers for the Kit ICCs are unknown. In this study, we treated adult mice with imatinib (a Kit signaling blocker) for 8 or 16 days and investigated whether CD44 is a specific marker for the Kit negative ICCs in the adult mouse colon.

[Influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma].

Objective: To discuss the influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma.

Methods: Sixty patients with severe burn or trauma hospitalized in the Third People's Hospital of Chongqing or Southwest Hospital of the Third Military Medical University from January 2010 to December 2011 were randomly divided into intensive insulin therapy group (IT, treated with intensive insulin therapy to control the blood glucose to the level of 6.0-8.

[Effects of intensive insulin therapy on inflammatory response and prognosis of patients with severe trauma].

Objective: To investigate the effects of intensive insulin therapy on inflammatory response and prognosis of patients with severe trauma.

Methods: Eighty severely injured patients were divided into intensive insulin therapy group (n = 40, IT) and routine therapy group (n = 40, RT) in random pair. At the time of admission, a continuous infusion of insulin (2-4 U/h) was pumped into the patients of IT group to maintain blood glucose level at 6-8 mmol/L.

[Influence of delayed rapid fluid resuscitation on oxygen metabolism in dogs with burn shock].

Objective: To investigate the influence of delayed rapid fluid resuscitation on oxygen metabolism in dogs with burn shock.

Methods: Twenty-four mongrel dogs inflicted with 40% TBSA full thickness scald were enrolled in the study and randomly divided into burn control (C), delayed even fluid replacement (E), and delayed rapid fluid replacement (R) groups, with 8 dogs in each group. The changes in oxygen delivery (DO(2)), oxygen consumption (VO(2)), oxygen extraction (O(2)ext) and blood base deficit (BD), and lactate (LA) were determined before scalding and at 2, 6, 8, 12, 24, 36 and 48 post scalding hours (PSHs).

[Effect of intensive insulin therapy on serum proinflammatory cytokine levels in patients with severe trauma].

Objective: To investigate the effect of intensive insulin therapy on serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C reaction protein (CRP), all of which reflected the inflammatory status in patients with severe trauma.

Methods: Forty patients with severe trauma [injury severity score (ISS)>or=20] were randomly divided into intensive insulin therapy group and control group. Enzyme-linked immunoadsorbent assay (ELISA) method was used to determine the TNF-alpha and IL-6 levels within 72 hours after admission.

Clinical study of a formula for delayed rapid fluid resuscitation for patients with burn shock.

Objective: To explore a suitable formula of delayed rapid fluid resuscitation for patients with burn shock.

Methods: Twenty patients with burns over 40% of total body surface area (TBSA) admitted 4-8 h after injury were studied. Plasma was used as colloid in 9 cases in the infused patients (the plasma group, PG) and gelofusine was used as colloid in 11 cases in the infused patients (the gelofusine group, GG).

[Clinical study of plasma substitute (Gelofusion) on fluid resuscitation in patients with burned shock].

Objective: To investigate the effects of plasma substitute(Gelofusion) on fluid resuscitation in patients with burned shock.

Methods: Twenty burn shock patients with total body surface area (TBSA) more than 40% were enrolled for clinical study on the effect of resuscitation with plasma substitute (Gelofusion). The patients were randomly divided into two groups: Gelofusion resuscitation group (n=11) and plasma resuscitation group (n=9).